The effect of synthetic acetylhexapeptide-8 (AH8) on sebaceous function / Vivian Y. Shi in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 44, N° 4 (08/2022)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 44, N° 4 (08/2022) . - p. 477-483 Titre : The effect of synthetic acetylhexapeptide-8 (AH8) on sebaceous function Type de document : document électronique Auteurs : Vivian Y. Shi, Auteur ; Waqas Burney, Auteur ; Anastasia Shakhbazova, Auteur ; Adrianne Pan, Auteur ; Lauren A. Hassoun, Auteur ; Shreya Sharma, Auteur ; Raja K. Sivamani, Auteur Année de publication : 2022 Article en page(s) : p. 477-483 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Acétylhexapeptide-8 Cosmétiques Dermo-cosmétologie Peau -- Soins et hygiène Séborrhée Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : This study aims to evaluate the in vitro and clinical effects of topical acetylhexapeptide-8 (AH8) on the appearance of oily skin. - Method : In vitro SEB-1 human sebocyte cell lines were exposed to different concentrations of AH8, then the lipid content of the sebocytes was measured. For the randomized, controlled, split-face clinical study, participants received AH8 10% lotion formulated in Cetaphil Moisturizing Facial Lotion on one side of their face and the control vehicle lotion on the other side of their face. Facial oiliness was assessed by a trained physician using a three-point grading system, high-resolution digital photographs, and a sebumeter (SM815). Participants also filled out self-assessments of their skin oiliness. - Results : The in vitro experiments showed that sebocyte lipid content significantly decreased after AH8 treatment (p < 0.05 at 0.00005% AH8, p = 0.09 at 0.0005% AH8, p < 0.05 at 0.005% AH8, and p < 0.001 at 0.025% AH8). In the clinical study, participants trended towards a 10% reduction (p = 0.16) in sebum production after AH8 treatment in comparison to the vehicle treatment. - Conclusion : AH8 inhibits the accumulation of lipids in sebocytes in vitro without altering cell proliferation or SREBP-1 expression. Topical AH8 trended towards decreased sebum production in human participants. The use of AH8 may serve as a promising agent to reduce sebocyte lipid production and the appearance of oily skin. DOI : https://doi.org/10.1111/ics.12795 En ligne : https://drive.google.com/file/d/1GaypXzW7f0AA6KAN0yhLqW26sTYf_-rl/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38147 [article]

Exemplaires

Code-barres	Cote	Support	Localisation	Section	Disponibilité
aucun exemplaire

---

1 (1 - 1 / 1)