The protective effect of a novel sunscreen against blue light Background and objective / Veronique Francois-Newton in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 44, N° 4 (08/2022)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 44, N° 4 (08/2022) . - p. 464-476 Titre : The protective effect of a novel sunscreen against blue light Background and objective Type de document : document électronique Auteurs : Veronique Francois-Newton, Auteur ; Vimi Lutchmanen Kolanthan, Auteur ; Madiiha Bibi Mandary, Auteur ; Evans Georges Philibert, Auteur ; Vitisha Soobramaney, Auteur ; Gitanjali Petkar, Auteur ; Bibi Nusayha Sokeechand, Auteur ; Muzzammil Hosenally, Auteur ; Andrea Cavagnino, Auteur ; Martin Andres Baraibar, Auteur ; Sue Phay Ng, Auteur Année de publication : 2022 Article en page(s) : p. 464-476 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Carbonylation Dermo-cosmétologie Lumière bleue Mélasma Le mélasma (également dénommé chloasme ou chloasma) est une affection bénigne de la peau se présentant sous la forme de taches hyperpigmentées apparaissant sur les zones exposées au soleil, surtout au niveau du visage, du décolleté et du cou. Le mélasma atteint principalement les femmes, le plus souvent lors de la grossesse, donnant ce que l'on appelle communément le masque de grossesse, mais il peut apparaître en dehors de celle-ci. Les causes et les facteurs favorisants du mélasma sont essentiellement des facteurs de prédisposition génétique, l’exposition au soleil et aux Å“strogènes (lors de la grossesse ou au cours d'une contraception). Peau -- Soins et hygiène Pigmentation de la peau Produits antisolaires Protéines Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Background and objective : Premature skin ageing, and skin hyperpigmentation are influenced by exogenous factors, such as ultraviolet radiation and blue light. In this study, we assess the protective effect of a sunscreen (TDF® Blu Voile Sunscreen) in protecting the skin against the harmful effects of blue light irradiation in vivo and through the in situ quantitative and qualitative evaluation of protein carbonylation in human skin explants. - Methodology : The protective effect of the test product against blue light was first evaluated ex vivo on human skin explants. The treated and non-treated explants were exposed to 14 J/cm2 of blue light 460 nm following which the protein carbonylation was evaluated by in situ epifluorescence imaging and separation by high-resolution gel electrophoresis. To determine whether the test product could also protect against the immediate and persistent pigmenting effect of blue light, two randomized in vivo studies were conducted, which included respectively 17 subjects with a skin phototype of IV and V (Fitzpatrick classification) and 22 subjects with a skin phototype of IV, V, and VI (Fitzpatrick classification). The duration of the study for each subject was 2 days (D1 and D2) for immediate observations and 5 days (D1–D5) for persistent observations. Specific zones on the subjects' back were either left non-treated or treated with the test product and were then exposed to a unique dose of blue light 415 nm. The onset of pigmentation between the treated and exposed zones was then assessed relative to the non-exposed treated zone through colorimetric measurements of the Individual Typology Angle (ITAo). - Results : Human skin explants treated with test product showed significantly lower levels of accumulated carbonylated proteins, with a protection of 82%, following exposure to blue light 460 nm. Findings of the in vivo studies also indicated that the test product presented significantly better protective efficacy against immediate and persistent pigmentation induced by blue light 415 nm. - Conclusion : Hence, it can be concluded that the test product can protect against the oxidative stress as well as the immediate and persistent pigmentation induced by blue light. Note de contenu : - MATERIALS AND METHODS : Test compounds - Blue lights doses - Ex vivo protein carbonylation study - Human skin explants preparation - In situ visualization and semi-quantification of carbonylated proteins - Extraction and absolute quantification of carbonylated proteins - Statistical analysis - In vivo clinical study with volunteers - Evaluation against the immediate pigmenting effect of blue light - Evaluation against the persistent pigmenting effect of blue light - Colorimetric measurement - Statistical analysis - RESULTS : Prevention against accumulation of carbonylated proteins in human skin explants - Protection against the immediate pigmenting effect of blue light - Illustrative photographs of immediate pigmentation - Protection against the persistent pigmenting effect of blue light - Table 1 : Experimental group and design - Table 2 : The study flow of the in vivo trial for immediate pigmentation effect of blue light - Table 3 : The study flow of the in vivo trials for persistent pigmentation effect of blue light DOI : https://doi.org/10.1111/ics.12794 En ligne : https://drive.google.com/file/d/1oEDQa-wCBoOiHBVvptrg1X1eEg6VkisC/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38146 [article]

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