| Titre : |
Ex vivo-In vivo correlation of retinol stratum corneum penetration studies by confocal Raman microspectroscopy and tape stripping |
| Type de document : |
document électronique |
| Auteurs : |
Richard Krombholz, Auteur ; Stefanie Fressle, Auteur ; Dominique Lunter, Auteur |
| Année de publication : |
2022 |
| Article en page(s) : |
p. 299-308 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Analyse spectrale
Barrière cutanée
Dermo-cosmétologie
Emulsions -- Emploi en cosmétologie
Microscopie confocale Raman
Pénétration cutanée
Vitamine A
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Skin penetration studies of topically applied drugs are a challenging topic in the development of semisolid formulations. The most commonly used methods can be differentiated by their character into ex vivo/in vivo, invasive/non-invasive and offline/in-line measurements. In this study, we compare ex vivo tape stripping, an invasive technique, which is often used, to confocal Raman microspectroscopy (CRM), ex and in vivo, to establish a correlation between those methods. Retinol was used as a model drug, applied in an oil-in-water emulsion, to compare the skin penetration profiles obtained by the different methods. |
| Note de contenu : |
- MATERIALS AND METHODS : Materials - Preparation of the retinol emulsion - Preparation of porcine ear skin - Incubation of porcine ear skin - Tape stripping - Retinol quantification by HPLC - Confocal Raman microspectroscopy (CRM) ex vivo/in situ - Retinol quantification by CRM - Confocal Raman microspectroscopy (CRM) in vivo - Data evaluation and statistics
- RESULTS : Ex vivo tape stripping - Ex vivo/in situ CRM - In vivo CRM |
| DOI : |
https://doi.org/10.1111/ics.12775 |
| En ligne : |
https://drive.google.com/file/d/1sA91sNCGXy5ZghRFSLH-LkB_5XpKDBVd/view?usp=shari [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38132 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 44, N° 3 (06/2022) . - p. 299-308
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