Recent strategies of collagen-based biomaterials for cartilage repair : from structure cognition to function endowment / Xiaoyue Yu in JOURNAL OF LEATHER SCIENCE AND ENGINEERING, Vol. 4 (Année 2022)  

[article]  inJOURNAL OF LEATHER SCIENCE AND ENGINEERING > Vol. 4 (Année 2022) . - 23 p. Titre : Recent strategies of collagen-based biomaterials for cartilage repair : from structure cognition to function endowment Type de document : texte imprimé Auteurs : Xiaoyue Yu, Auteur ; Haiping Zhang, Auteur ; Yiliang Miao, Auteur ; Shanbai Xiong, Auteur ; Yang Hu, Auteur Année de publication : 2022 Article en page(s) : 23 p. Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Biopolymères Cartilage Collagène Ingénierie tissulaire Polymères en médecine Régénération (biologie) Index. décimale : 668.9 Polymères Résumé : Collagen, characteristic in biomimetic composition and hierarchical structure, boasts a huge potential in repairing cartilage defect due to its extraordinary bioactivities and regulated physicochemical properties, such as low immunogenicity, biocompatibility and controllable degradation, which promotes the cell adhesion, migration and proliferation. Therefore, collagen-based biomaterial has been explored as porous scaffolds or functional coatings in cell-free scaffold and tissue engineering strategy for cartilage repairing. Among those forming technologies, freeze-dry is frequently used with special modifications while 3D-printing and electrospinning serve as the structure-controller in a more precise way. Besides, appropriate cross-linking treatment and incorporation with bioactive substance generally help the collagen-based biomaterials to meet the physicochemical requirement in the defect site and strengthen the repairing performance. Furthermore, comprehensive evaluations on the repair effects of biomaterials are sorted out in terms of in vitro, in vivo and clinical assessments, focusing on the morphology observation, characteristic production and critical gene expression. Finally, the challenge of biomaterial-based therapy for cartilage defect repairing was summarized, which is, the adaption to the highly complex structure and functional difference of cartilage. Note de contenu : - STRUCTURE AND DEFECTS OF CARTILAGE : The composition of articular cartilage - Hierarchical structure of articular cartilage - The etiology and degree of cartilage defect - Current repair strategies - - STRUCTURE AND FUNCTION OF COLLAGEN : Hierarchical structure of COL I - The role of COL I in cartilage repair - DESIGN AND PREPARATION OF COLLAGEN-BASED BIOMATERIALS FOR CARTILAGE DEFECT REPAIR : Forming and cross-linking of collagen-based biomaterials - Incorporated fabrication of collagen-based biomaterials for cartilage repair - COMPREHENSIVE EVALUATIONS OF CARTILAGE REPAIR BY COLLAGEN-BASED BIOMATERIALS : Physicochemical properties - Bioactivities for cartilage repair - Clinical diagnosis - Table 1 : General methods used to evaluate the bioactivities of biomaterials DOI : https://doi.org/10.1186/s42825-022-00085-4 En ligne : https://link.springer.com/content/pdf/10.1186/s42825-022-00085-4.pdf Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=37578 [article]

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