Bletilla striata polysaccharide modified collagen fiber composite sponge with rapid hemostasis function / Xingyu Yan in JOURNAL OF LEATHER SCIENCE AND ENGINEERING, Vol. 4 (Année 2022)  

[article]  inJOURNAL OF LEATHER SCIENCE AND ENGINEERING > Vol. 4 (Année 2022) . - 15 p. Titre : Bletilla striata polysaccharide modified collagen fiber composite sponge with rapid hemostasis function Type de document : texte imprimé Auteurs : Xingyu Yan, Auteur ; Yining Chen, Auteur ; Weihua Dan, Auteur ; Nianhua Dan, Auteur ; Zhengjun Li, Auteur Année de publication : 2022 Article en page(s) : 15 p. Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Biopolymères Caractérisation Collagène Composites à fibres Polymères en médecine Polysaccharides microbiens Index. décimale : 668.9 Polymères Résumé : Emergencies often result in uncontrollable bleeding, which is thought to be the leading cause of death at the scene of the injured. Among various hemostasis scenarios, collagen fiber (CF) is gradually replacing traditional hemostatic materials due to its superior properties and ease of sourcing from animals. Herein, we use CF and the natural herbaceous Bletilla striata as raw materials to prepare a collagen fiber-oxidized Bletilla striata composite hemostatic sponge (CFOB). During the cross-linking process, the triple helix structure of collagen stays intact, and its porous three-dimensional network structure brings excellent bulkiness and water absorption properties. Experiments show that the optimal amount of sponge CFOB-10, namely oxidized Bletilla striata polysaccharide 0.5 mg/mL and CF 5 mg/mL, only needed 25 ± 4.06 s for hemostasis time in the rat liver hemorrhage model. In addition, CFOB meets the safety performance requirements of cytotoxicity classification standard 0. Therefore, the optimal amount of CFOB is an excellent new hemostatic material with application potential. Note de contenu : - EXPERIMENTS AND METHODS : Experimental instruments and equipment - Main reagents and materials - Preparation method - Characterization method - RESULTS : FT-IR spectra measurements - CD spectral analysis - Differential scanning calorimetry (DSC) - AFM and SEM - Determination of water absorption and porosity ratio - Hemolysis assay - Activated partially thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) - Evaluation of cell compatibility - Whole-blood clotting assay (CT) - Blood clotting assay in vitro - Evaluation of in vivo hemostatic performance - Analysis of coagulation mechanism and synergy DOI : https://doi.org/10.1186/s42825-022-00079-2 En ligne : https://link.springer.com/content/pdf/10.1186/s42825-022-00079-2.pdf Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=37573 [article]

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