Development of leachable enalapril tablets by controlled porosity osmotic pump technique ; a unique approach to enhance its sustained release effect / Muhammad Faheem Akhtar in JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH, Vol. 19, N° 2 (03/2022)  

[article]  inJOURNAL OF COATINGS TECHNOLOGY AND RESEARCH > Vol. 19, N° 2 (03/2022) . - p. 497-507 Titre : Development of leachable enalapril tablets by controlled porosity osmotic pump technique ; a unique approach to enhance its sustained release effect Type de document : texte imprimé Auteurs : Muhammad Faheem Akhtar, Auteur ; Hira Ashraf, Auteur ; Muhammad Uzair, Auteur ; Shabbir Ahmad, Auteur ; Akhtar Rasul, Auteur ; Ghulam Abbas, Auteur ; Shahid Shah, Auteur ; Muhammad Hanif, Auteur Année de publication : 2022 Article en page(s) : p. 497-507 Note générale : Bibliogr. Langues : Américain (ame) Catégories : Acétate de cellulose L'acétate de cellulose est une matière plastique inventée en 1865. C'est l'ester acétate de la cellulose. Agent osmotique Médicaments -- Mise au point Membranes (technologie) Tags : CPOP  'Membrane  lixiviable'  'Agent  osmotique'  'Acétate  de  cellulose'  'Conception  surface  réponse  optimale  D' Index. décimale : 667.9 Revêtements et enduits Résumé : The present study aimed to design and evaluate controlled porosity osmotic pump (CPOP) tablets of enalapril maleate (ENP) being used for the treatment of hypertension. D-optimal response surface design was used, considering cellulose acetate and osmotic agents (lactose and fructose) as variables while physicochemical parameters of tablets were taken as responses. The asymmetric, leachable membrane of cellulose acetate on ENP tablets was applied and an increase in the thickness of core tablets from 5 ± 0.01 to 5.4 ± 0.17 mm was observed. The average weight of all CPOP formulations ranged from 376.7 ± 0.4 to 389.1 ± 0.3 mg and hardness was 6.2 ± 0.02 to 6.32 ± 0.06 Kg/cm2. The friability of all formulations was less than 1%. 89.53 ± 1.05% of ENP release was observed in phosphate buffer pH 6.8 after 12 h. Due to the smallest AIC (Akaike information criteria) and the greatest r2 values, zero-order release kinetics model with non-Fickian diffusion behavior was observed in all proposed formulations. f1 (difference factor) values were 1.28 ± 0.06 to 12.64 ± 0.41% and f2 (similarity factor) values were 59.75 ± 0.24 to 94.03 ± 1.36% in the same dissolution medium. pH-independent behavior was observed in pH-responsive study. Dissolution efficiency (DE) ranged from 51.49 ± 0.23 to 53.52 ± 0.52% and mean dissolution time (MDT) values ranged from 5.27 ± 0.05 to 5.59 ± 0.23 h. No interaction between the ingredients was found in FTIR analysis. The optimized formulation with improved drug release property was found stable in the accelerated stability study of six months. CPOP tablets of ENP can be considered as an effective substitute for immediate-release tablets to control hypertension in chronic conditions. Note de contenu : - MATERIALS AND METHODS : Materials - Experimental design - Preformulation studies - Preparation of core tablets - Preparation of CPOP tablets - Physicochemical evaluation of core and CPOP tablets - In vitro ENP release studies - Effects of osmotic agent and cellulose acetate concentrations - Effects of pH and agitational intensity - FTIR analysis and stability study - RESULTS AND DISCUSSION : Preformulation properties of powder blends - Physical properties of core and CPOP tablets - D-optimal design responses - In vitro ENP release studies - Effects of osmotic agent and cellulose acetate concentrations on %ENP release - Effects of pH and agitational intensity on % ENP release through CPOP tablets - FTIR analysis and stability study - Table 1 : Coded factors* for D-optimal design - Table 2 : Composition of controlled porosity osmotic pump tablets with varying concentrations of osmotic agents and coating polymer. ENP, magnesium stearate, and average weight of core tablet were kept constant at 5.33% (20 mg), 1%, and 375 mg, respectively. DCM/methanol (1:1) was used as a coating solvent, PEG-400 used in coating solution was 15% of CA* - Table 3 : Micromeritic and physicochemical properties of core and CPOP tablets - Table 4 : Statistics obtained from in vitro model-dependent kinetic approaches of controlled porosity osmotic pump tablets - Table 5 : Values of difference factor (f1) and similarity factor (f2) for CPOP tablets - Table 6 : Characteristics of optimized formulation (CPOP2) stored at 40 ± 2°C/75 ± 5% RH for six months DOI : https://doi.org/10.1007/s11998-021-00536-3 En ligne : https://link.springer.com/content/pdf/10.1007/s11998-021-00536-3.pdf Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=37281 [article]

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