Investigating the influence of excipient batch variation on the structure, consistency and physical stability of polysorbate 60–based topical vehicles / Hoang Vu Dang in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° 6 (12/2021)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° 6 (12/2021) . - p. 715-728 Titre : Investigating the influence of excipient batch variation on the structure, consistency and physical stability of polysorbate 60–based topical vehicles Type de document : document électronique Auteurs : Hoang Vu Dang, Auteur ; Hung Tran Huu, Auteur ; Hue Minh Thi Nguyen, Auteur Année de publication : 2021 Article en page(s) : p. 715-728 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Alcools gras Analyse thermique Calorimétrie Chromatographie en phase gazeuse Chromatographie en phase liquide Emulsions -- Emploi en cosmétologie Ingrédients cosmétiques Microscopie Polyéthylène glycol Polysorbates Rayons X -- Diffusion Rhéologie Index. décimale : 668.5 Parfums et cosmétiques Résumé : Fatty alcohol-polysorbate 60-water ternary systems were used as models to represent the continuous phases of the respective semisolid oil-in-water emulsions for topical delivery of cosmetic and medicinal agents. The influence of batch variation of polysorbate 60 and fatty alcohol on structure and consistency of these systems was investigated using microscopy, rheology, differential scanning calorimetry and X-ray scattering techniques. The polysorbate 60 : cetostearyl alcohol mixed emulsifying wax showed swelling in water, that is, the lamellar repeat distance continually augmented from 93 to 125 Ã… with water percentage 20–90%. Cetostearyl alcohol ternary systems were thicker than cetyl alcohol ones independently of polysorbate 60 batches used. All the ternary systems showed an initial increase in consistency over the first 2 weeks of storage, which was followed by slight changes in consistency (cetostearyl alcohol systems) due to the re-allocation of polysorbate 60 molecules in the gel network or significant breakdown of structure (cetyl alcohol systems) due to the transformation of swollen α-lamellar gel phase into β, γ crystals on 25°C storage. With all fatty alcohols, the consistency of polysorbate 60 ternary system was directly dependent upon interlamellar water thickness as governed by the length and distribution of polyoxyethylene groups within polysorbate 60 molecules. In relation with the composition of polysorbate 60 batches used, the consistency of ternary systems was higher when prepared with the polysorbate 60 batch containing a greater amount of sorbitan polyoxyethylene monoesters. It was proposed that the swollen α-crystalline gel phase could be better formed by sorbitan polyoxyethylene monoesters rather than sorbitan polyoxyethylene diesters. Note de contenu : - MATERIALS AND METHODS : Materials - Gas chromatography (GC) analysis of fatty alcohols - Liquid chromatography-mass spectrometry (LC-MS) analysis of polysorbate 60 batches - Preparation of ternary systems - Macroscopic and microscopic observation - Differential scanning calorimetry (DSC) - X-ray scattering - RESULTS : GC data of fatty alcohols - LC-MS data of polysorbate 60 - Macroscopic and microscopic observation - DSC data - Rheological data - X-ray scattering data - Table 1 : GC analysis data of batches of fatty alcohols used - Table 2 : Experimental calculation of creep curve analysis of CSA1–B1/B2 polysorbate 60 – water systems (n = 3, RSD < 2%) DOI : https://doi.org/10.1111/ics.12747 En ligne : https://drive.google.com/file/d/1q9nm1dcGjMhpuy1CKQfuktkKZRAT_e6l/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=37052 [article]

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