Investigation of the molecular signature of greying hair shafts / Raoul Vyumvuhore in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° 3 (06/2021)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° 3 (06/2021) . - p. 332-340 Titre : Investigation of the molecular signature of greying hair shafts Type de document : document électronique Auteurs : Raoul Vyumvuhore, Auteur ; Laurie Verzeaux, Auteur ; Sophie Gilardeau, Auteur ; Sylvie Bordes, Auteur ; Elodie Aymard, Auteur ; Michel Manfait, Auteur ; Brigitte Closs, Auteur Année de publication : 2021 Article en page(s) : p. 332-340 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Cheveux -- Biologie Cheveux -- Blanchiment Cheveux -- Croissance Spectroscopie Raman Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Hair greying (i.e. canitie) is a physiological process occurring with the loss of melanin production and deposition within the hair shafts. Many studies reported the oxidation as the main biological process underlying this defect of pigmentation. Even though the overall appearance and biomechanical properties of hairs are reported to be altered with greying, there is a lack of information about molecular modifications occurring in grey hair shafts. The aim of this study was thus to investigate the molecular signature and associated changes occurring in greying hair shafts by confocal Raman microspectroscopy. - Methods : This study was conducted on pigmented, intermediate (i.e. grey) and unpigmented hairs taken from 29 volunteers. Confocal Raman microspectroscopy measurements were acquired directly on hair shafts. - Results : Automatic classification of Raman spectra revealed 5 groups displaying significant differences. Hence, the analysis of the molecular signature highlighted the existence of 3 sub-groups within grey hair : light, medium and dark intermediate. Among molecular markers altered in the course of greying, this study identified for the first time a gradual modification of lipid conformation (trans/gauche ratio) and protein secondary structure (α-helix/β-sheet ratio), referring respectively to an alteration of barrier function and biomechanical properties of greying hair. - Conclusion : This study thus reports for the first time a highly specific molecular signature as well as molecular modifications within grey hair shaft. Note de contenu : - METHODS : Hair samples - Confocal Raman microspectroscopy - RESULTS : Classification of hair Raman spectra by hierarchical cluster analysis (HCA) - Investigation of oxidation markers in greying hair shafts - Modifications in lipid conformation and protein secondary structure in greying hair - - Table 1 : Characteristics of Raman bands analysed on hair fibres DOI : https://doi.org/10.1111/ics.12700 En ligne : https://drive.google.com/file/d/19u0bfXQXgLq1GPDGe8mTp5q6Xd9T8p8U/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35900 [article]

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