Permeability coefficients and vapour pressure determination for fragrance materials / Rafael N. Almeida in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° 2 (04/2021)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° 2 (04/2021) . - p. 225-234 Titre : Permeability coefficients and vapour pressure determination for fragrance materials Type de document : document électronique Auteurs : Rafael N. Almeida, Auteur ; João G. M. Hartz, Auteur ; Patrícia F. Costa, Auteur ; Alirio E. Rodrigues, Auteur ; Rubem M. F. Vargas, Auteur ; Eduardo Cassel, Auteur Année de publication : 2021 Article en page(s) : p. 225-234 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Caractérisation Evaporation Franz, Cellules de Modèles numériques Parfums Pénétration (physique) Statistiques Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : This study aims to correlate new experimental data relevant to the description of the combined evaporation/permeation process of a perfume applied onto the skin. - Methods : The vapour pressure data were measured by thermogravimetric analysis (TG-DTA). The Antoine constants and the Clarke and Glew parameters were determined for the same set of fragrance molecules to describe its low vapour pressures at new temperature ranges. The permeability coefficient of a set of 14 fragrance molecules in ethanolic solution was determined by Franz diffusion cell experiments, using porcine skin. The samples were analysed by gas chromatography with a flame ionization detector (GC/FID) and high-performance liquid chromatography with UV visible detector (HPLC/UV). A QSAR model was proposed to correlate the experimental data. - Results : The Antoine constants were determined and presented low standard deviations. The Clarke and Glew physically significant parameters were obtained along with its statistical analysis. The fitting is good since the magnitude order is in accordance with the literature, associated with the low correlation between the estimated parameters and low standard deviations. The presented correlation, based on a mixture using only ethanol as solvent, showed better results than previous QSAR models with a standard relative deviation (δr) of 0.190, a standard error (SE) of 0.397 and a determination coefficient (R2) of 0.7786. - Conclusion : The dataset is still small compared to larger and more general QSAR models; however, it is much more specific as to the type of solvent and class of materials studied. This work represents an advance for the modelling of the perfume diffusion process since it specifies important properties that until then had been treated in a more general way. Note de contenu : - MATERIALS AND METHODS : Chemicals - Pig ears skin preparation - In vitro skin permeation - Quantification - Vapour pressure - Permeability coefficient and QSAR model - RESULTS AND DISCUSSION : Vapour pressure - Permeability coefficient - Table 1 : Properties of the fragrance materials - Table 2 : Antoine estimated vapour pressure parameters - Table 3 : Parameters of Clarke and Glew equation derived from vapour pressure data at the reference temperatureθ = 298.15 K and pressureP0 = 105 Pa - Table 4 : Experimental and correlated skin permeability coefficients of the studied fragrance materials DOI : https://doi.org/10.1111/ics.12686 En ligne : https://drive.google.com/file/d/18HTF-vxqg4d2pCyRDXWoFdF7xZbCKBPZ/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35874 [article]

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