Pigmentation effects of blue light irradiation on skin and how to protect against them / Remo Campiche in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 42, N° 4 (08/2020)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 42, N° 4 (08/2020) . - p. 399-406 Titre : Pigmentation effects of blue light irradiation on skin and how to protect against them Type de document : document électronique Auteurs : Remo Campiche, Auteur ; S. J. Curpen, Auteur ; V. Lutchmanen-Kolanthan, Auteur ; Sarah Gougeon, Auteur ; Marie Cherel, Auteur ; G. Laurent, Auteur ; Mathias Gempeler, Auteur ; R. Schuetz, Auteur Année de publication : 2020 Article en page(s) : p. 399-406 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Algues d'eau douce Biomolécules actives Formulation (Génie chimique) Lumière artificielle -- Effets physiologiques Lumière bleue Nicotinamide Pigmentation, Troubles de la Statistique Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Background : Visible light, in particular blue light, has been identified as an additional contributor to cutaneous photoageing. However, clinical studies demonstrating the clear effect of blue light on photoageing are still scarce, and so far, most studies have focused on broad-spectrum visible light. Although there is evidence for increased skin pigmentation, the underlying mechanisms of photoageing in vivo are still unclear. Furthermore, there is still a need for active ingredients to significantly protect against blue light-induced hyperpigmentation in vivo. Our study had two aims: to detect visible changes in skin pigmentation following repeated irradiation of the skin with LED-based blue light and to reduce pigmentation using suitable active ingredients. - Method : We conducted a randomized, double-blind and placebo-controlled clinical study on 33 female volunteers with skin phototypes III and IV. We used a repetitive blue light (4 × 60 J cm−2, 450 nm) irradiation protocol on the volunteers’ inner forearms. Using hyperspectral imaging, we assessed chromophore status. In addition, we took chromameter measurements and photographs to assess visible hyperpigmentation. - Results : We measured significant changes in chromophore status (P < 0.001 vs baseline), that is of melanin, haemoglobin and oxygen saturation, immediately after blue light irradiation. In addition, we found visible skin colour changes which were expressed by a significant decrease in ITA° values (delta ITA° = -16.89, P < 0.001 vs baseline for the placebo group) and an increase in a* (delta a* = +3.37, P < 0.001 vs baseline for the placebo group) 24 h post-irradiation. Hyperpigmentation and skin reddening were mitigated by both a formulation containing 3% of a microalgal product and a formulation containing 3% niacinamide. - Conclusion : Our study sets out an efficient and robust protocol for investigating both blue light-induced cutaneous alterations, such as changes in skin chromophores, and signs of photoageing, such as hyperpigmentation. Moreover, we have shown evidence that both an extract of the microalga Scenedesmus rubescens and niacinamide (vitamin B3) have the potential to protect against blue light-induced hyperpigmentation. Note de contenu : - MATERIALS AND METHODS : Test compounds - Blue light source - Clinical study design - Statistical analysis - RESULTS : Blue light‐induced changes in skin chromophores - Blue light‐induced changes in skin colour - Table 1 : Formulations used in this study DOI : https://doi.org/10.1111/ics.12637 En ligne : https://drive.google.com/file/d/1LwcZLPEyAn7hYOz0vljrQ_rPWJ1WpkLk/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35291 [article]

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