[article]
| Titre : |
New ingredient from Rosa rugosa delays skin ageing |
| Type de document : |
texte imprimé |
| Auteurs : |
Annalisa Tito, Auteur ; Claudia Zappelli, Auteur ; Maura Angelillo, Auteur ; Maria Gabriella Colucci, Auteur ; Fabio Apone, Auteur |
| Année de publication : |
2020 |
| Article en page(s) : |
p. 131-137 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge
Caractérisation
Cellules -- Cultures et milieux de culture
Chimie analytique
Cosmétiques
Elisa, TestLe test ELISA est une méthode de laboratoire qualifiée d'immuno-enzymatique. Il s'agit d'un test immunologique, car il a pour principal objectif de mettre en évidence la présence d'anticorps ou d'antigènes spécifiques à une pathologie, dans un échantillon de sang. Cet examen utilise une protéine appelée enzyme, qui va se fixer à certains constituants spécifiques de la maladie, et par repérage et quantification de cette enzyme, la maladie pourra être affirmée, ainsi que son intensité évaluée.
Expression génique
Extraits de plantes:Extraits (pharmacie)
Fibroblastes
Peau -- Soins et hygiène
Statistique
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Skin ageing is an inevitable physiological process, determined by several concomitant factors, resulting in a thinner and drier skin, in the formation of fine wrinkles, and a gradual dermal atrophy.
During this process the skin cells become senescent, they slow down their metabolism and the production of structural matrix components. The Growth Differentiation Factor 11 (GDF11) has been recently identified as a pro-youth factor in several cell types, and in particular it was shown its involvement in the restoration of a young phenotype in skin fibroblasts, by stimulating important ExtraCellular Matrix proteins. Furthermore, its key role in modulating mitochondrial functions in skin cells during ageing has been highlighted. In the present article, we describe the characterisation of a plant extract, obtained from Rosa rugosatissue cultures, able to produce a ‘rejuvenating’ effect in aged skin fibroblasts by inducing GDF11 expression and synthesis. The extract was also capable of increasing the expression of PGC1alpha, the master regulator of the mitochondrial biogenesis, and other important genes involved in the pathway, leading to an improvement of cell metabolism and longevity. |
| Note de contenu : |
- MATERIALS AND METHODS : Plant tissue cultures - Chemical analyses - Cell cultures and reagents for cell bioassays - ELISA assays - Gene expression analysis in HDF - Smad2 reporter assay - ATP content determination - Statistical analyses - Clinical tests
- RESULTS AND DISCUSSION : Preparation of the Rosa rugosa extracts and cytotoxicity assay - Activity of the Rosa rugosa extracts on the expression of GDF11, Sirtuins 1 and Sirtuin 6 - Chemical analysis of the Rosa rugosa somatic embryo extract- Activities of the Rosa rugosa somatic embryo extract on mitochondria - Activities of the Rosa rugosasomatic embryo extract on collagen and GDF11 production - Clinical tests with the Rosa rugosasomatic embryo extract |
| En ligne : |
https://drive.google.com/file/d/14RZdDOU35aptcxwYpk23FioS_DVj6Y6g/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33962 |
in PERSONAL CARE EUROPE > Vol. 14, N° 2 (04/2020) . - p. 131-137
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