| Titre : |
A Swiss glacier bacterium to vitalize tired skin |
| Type de document : |
texte imprimé |
| Auteurs : |
Christina Pickel, Auteur ; Franziska Wandrey, Auteur ; Daniel Schmid, Auteur ; Bernhard Henes, Auteur ; Fred Zülli, Auteur |
| Année de publication : |
2020 |
| Article en page(s) : |
p. 2-7 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Actifs anti-fatigue (cosmétique)
Antiâge:Antirides
Bactéries
Cosmétiques
Dermo-cosmétologie
Extraits de plantes:Extraits (pharmacie)
Fibroblastes
Molécules chaperonnes
Peau -- Soins et hygiène
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Today’s society is characterized by demanding jobs, long working hours and an increasingly hectic lifestyle, which frequently results in a lack of sleep. This is often markedly reflected of the skin by a tired appearance of the face. Recent research showed that also on the molecular level, lack of sleep causes stress and leads to premature aging. A major stress mechanism, the unfolded protein response (UPR) of the endoplasmic reticulum (ER), gets compromised by sleep deprivation, leading to the accumulation of misfolded proteins which damage the cell. To target this novel cellular aging mechanism, an extract of the psychrotolerant Swiss glacier bacterium Iodobacter ssp. was developed and analyzed for its efficacy to reduce ER stress and visible signs of tiredness. Treatment of aged fibroblasts with the extract led to an increase in the expression of ER chaperones which mediate the UPR and energized cells through an increase of ATP levels in a cellular model of sleep deprivation. Placebo-controlled randomized clinical studies conducted with sleep-deprived and overworked volunteers demonstrated that treatment with the Iodobacter-derived active ingredient IceAwake™ improved several skin parameters associated with skin aging, leading to a vitalized and rejuvenated appearance. |
| Note de contenu : |
- INTRODUCTION : Lack of sleep impacts on the cellular stress response - Harnessing the potential of extremophile organisms - A freshness kick for tired skin with a swiss glacier bacterium
- METHODS AND RESULTS : Iodobacter ssp. extract re-activates chaperone expression in aged fibroblasts - ER stress is reduced by iodobacter ssp. extract in a cellular model of sleep deprivation - IceAwakeTM ameliorate visible signs of tiredness in mixed study population
- Fig. 1 : Gene expression of chaperone genes in aged fibroblasts treated with Iodobacter ssp. extract relative to untreated cells
- Fig. 2 : ATP levels in AD fibroblasts upon treatment with Iodobacter ssp. extract relative to untreated cells
- Fig. 3 : Quantification of MAM contact points in healthy cells or AD fibroblasts treated with the Iodobacter active or left untreated
- Fig. 4 : Immunofluorescence staining of MAM contact points in healthy cells or AD fibroblasts treated with the Iodobacter active or left untreated
- Fig. 5 : Decrease of wrinkle depth upon treatment with IceAwakeâ„¢
- Fig. 6 : Reduction of tired appearance upon treatment with IceAwakeâ„¢
- Fig. 7 : Visible improvement of wrinkle depth and dark circles with IceAwakeâ„¢
- Fig. 8 : Increase in radiance with IceAwakeâ„¢ |
| En ligne : |
https://drive.google.com/file/d/1loBLI9V-EftSW37JaxNslSg-kvYiOCzi/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33820 |
in SOFW JOURNAL > Vol. 146, N° 3 (03/2020) . - p. 2-7
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