Cosmetic benefits of a novel biomimetic lamellar formulation containing niacinamide in healthy females with oily, blemish-prone skin in a randomized proof-of-concept study / Joao-Paulo Santos-Caetano in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 42, N° 1 (02/2020)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 42, N° 1 (02/2020) . - p. 29-35 Titre : Cosmetic benefits of a novel biomimetic lamellar formulation containing niacinamide in healthy females with oily, blemish-prone skin in a randomized proof-of-concept study Type de document : texte imprimé Auteurs : Joao-Paulo Santos-Caetano, Auteur ; C. F. Gfeller, Auteur ; H. Mahalingam, Auteur ; M. Thompson, Auteur ; David J. Moore, Auteur ; R. Vila, Auteur ; R. Doi, Auteur ; M.R. Cargill, Auteur Année de publication : 2020 Article en page(s) : p. 29-35 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Barrière cutanée Chimie biomimétique Cosmétiques Imperfections cutanées Peau -- Anatomie Peau -- Physiologie Peau -- Soins et hygiène Produits hydratants Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : A randomized study was designed to evaluate the potential cosmetic benefit of a biomimetic, niacinamide-containing moisturizing cream in oily, blemish-prone skin. - Methods : Healthy adult women with oily, blemish-prone skin were randomized to one of three treatment groups: test, control, or positive control. In the test group, subjects used the test product (containing 4% niacinamide), plus the standard cleanser (Simple® Kind to Skin Moisturizing Facial Wash). In the control group, subjects received no moisturizer but used the standard cleanser. In the positive control group, subjects used Vivatinell Acnecinamide® Gel Cream (containing 4% niacinamide) as a moisturizer and Neutrogena Visibly Clear® Spot Clearing Facial Wash (containing 2% salicylic acid) as a cleanser. The positive control regimen was included to provide a comparison for estimates of effect size. The primary objective was to evaluate skin moisturization as a change from baseline in corneometer values at 8 h for the test regimen vs. the control regimen. Analysis of covariance was applied for the primary efficacy analysis. - Results : A total of 132 subjects were randomized with 44 included in each treatment group. A significant difference was observed in the primary endpoint for the test regimen compared with the control regimen (least-squares mean difference [95% CI]: 3.12 [0.68, 5.56], P = 0.0128). A trend was observed in favour of the positive control regimen compared with the control regimen. Secondary measurements of moisturization supported the primary efficacy outcome. Assessment of blemishes showed a significant difference between the test regimen vs. the control regimen for change from baseline in mean total blemish count at Week 8 (least-squares mean difference [95% CI]: −1.80 [−3.41, −0.19], P = 0.0290). No statistical comparisons between the positive control group and the test group were performed. - Conclusion : This study provides proof-of-concept evidence that a novel lamellar lipid moisturizer containing niacinamide, in combination with a standard cleanser, can help moisturize the skin and provide an overall improvement in the complexion appearance of people with blemish-prone skin. Study registration: NCT03093181. Note de contenu : - METHODS : Subjects - Design - Assessments - Statistical methods - RESULTS : Primary efficacy - Secondary efficacy - Safety DOI : 10.1111/ics.12576 En ligne : https://drive.google.com/file/d/1yFFe46u8huUJT2o9csN_WMN-a8Ai8-rU/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33676 [article]

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