[article]
| Titre : |
Synchronized in vivo measurements of skin hydratation and trans-epidermal water loss. Exploring their mutual influences |
| Type de document : |
texte imprimé |
| Auteurs : |
E. Caberlotto, Auteur ; C. Cornillon, Auteur ; S. Njikeu, Auteur ; M. Monot, Auteur ; M. Vicic, Auteur ; Frédéric Flament, Auteur |
| Année de publication : |
2019 |
| Article en page(s) : |
p. 437-442 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Dermo-cosmétologie
Etudes cliniques
Hydratation
Mesure
Perte insensible en eau
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : To explore the relationship between skin surface hydration and Trans-Epidermal Water Loss (TEWL) when simultaneously measured.
- Methods : Six circular skin areas of the forearms (3 per forearm, 3 cm in diameter) of 12 Caucasian women were used as models. 4 prototypes of formulae of different compositions containing glycerol at different concentrations 7%, 10% and 40% were used as models of hydrating products. One formula (glycerol-free) was used as control vehicle. Standardized applications of formulae (2 mg/cm2) were performed on 5 skin sites chosen at random, the other being left as bare/control. A recently marketed instrumental device that records the skin surface hydration and TEWL on a small skin area in a simultaneous manner was used. Measurements were carried out at T0 (pre-application), at 1 h (T1) and 5 h (T5) post applications on two close sites within the 6 defined areas of both forearms.
- Results : The new instrumental device allowed to clearly differentiate the 5 formulae (i.e. 7% vs. 10%) with regard the dose effect brought by glycerol (7%, 10%, 40%) and to record their lingering effects at T1 and T5. Both parameters were found significantly and negatively correlated, i.e. the higher the skin hydration, the lower the TEWL. The 40% concentration of glycerol, that leads to the highest skin hydration, brings a drop in the TEWL by about a two-fold factor. Skin hydration of bare skin and control/vehicle sites showed minor and non-significant changes along 5 h. Instead, the control/ vehicle slowed down the TEWL to a slight extent.
- Conclusion : The use of this new instrumental device shed a new light on the mutual and inverse relationships between skin hydration and TEWL. Results suggest that, at high concentration, glycerol leads to largely increase the water content of both epidermal and dermal compartments, possibly leading to structural changes in the skin relief. |
| Note de contenu : |
- MATERIAL AND METHODS : The GPSkin Barrier system - Subjects & Skin sites - Tested formulae - Protocol - Statistics
- RESULTS : Skin hydratation - Trans-epidermal water loss (TEWL) - Correlation between both parameters |
| DOI : |
10.1111/ics12556 |
| En ligne : |
https://drive.google.com/file/d/1UVWeF6J_dNx6iTq-9_9UU888xT3M-BzP/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33201 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 41, N° 5 (10/2019) . - p. 437-442
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