| Titre : |
Molecular modeling of N-terminal telopeptides of bovine type I collagen |
| Type de document : |
texte imprimé |
| Auteurs : |
Phoebe X. Qi, Auteur ; Eleanor M. Brown, Auteur |
| Année de publication : |
2002 |
| Article en page(s) : |
p. 235-243 |
| Note générale : |
Bibliogr. |
| Langues : |
Américain (ame) |
| Index. décimale : |
675 Technologie du cuir et de la fourrure |
| Résumé : |
Functionality, both biological and technological, follows from protein structure. Computer-assisted molecular modeling is a useful tool for visualizing structure-function relationships in proteins. A model of the triple helical portion of a bovine type I collagen microfbril was previously developed in our laboratory for use in studies of mechanisms of collagen crosslinking and modification. This model has now been enhanced by the addition of the N-terminal, nonhelical, telopeptides. The telopeptide region is highly flexible, allowing reactive side-chains of residues such as lysine to assume conformations favorable for interaction with adjacent triple helix chains. All naturally occurring collagen crosslinks are anchored in the telopeptide region. This enhancement to our model will enable us to visualize the effects of enzymatic crosslinking on collagen structure and stability. The current model is now more useful for studying mechanisms of inter- and intramicrofibril crosslinking of collagen by chemical and biochemical methods. The potential for transglutaminase crosslinking of collagen is explored with the model. |
| En ligne : |
https://drive.google.com/file/d/1fyvNuAYfLxmLsoCIHZYmi-Oin2CYU_Oo/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=4292 |
in JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA) > Vol. XCVII, N° 6 (06/2002) . - p. 235-243
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Molecular modeling of N-terminal telopeptides of bovine type I collagen in JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA), Vol. XCVII, N° 6 (06/2002)
