| Titre : |
Effects of eczema calming lotion on the stratum corneum in atopic dermatitis : Corneodesmosin and intercellular lipid lamellae |
| Type de document : |
texte imprimé |
| Auteurs : |
Hilal Ilarslan, Auteur ; William F. Lathrop, Auteur ; Brian Dobkowski, Auteur ; Stacy S. Hawkins, Auteur ; Jane Scott, Auteur ; John Bajor, Auteur ; Andrew E. Mayes, Auteur |
| Année de publication : |
2024 |
| Article en page(s) : |
p. 516-525 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Barrière cutanée
cornéodesmosineLa cornéodesmosine est synthétisée au sein des kératinocytes épineux supérieurs. Sécrétée par l’intermédiaire des corps lamellaires, la cornéodesmosine est secondairement incorporée au niveau du cœur des desmosomes. Il s’agit de la seule protéine identifiée à ce jour comme étant spécifique des cornéodesmosomes. Son contenu riche en résidus sérine et glycine s'organisant en boucles souples est compatible avec des fonctions d’adhésion. (https://biologiedelapeau.fr/)
Cornéosomes
Couche cornée
Dermo-cosmétologie
Dermo-pharmacie
Eczéma constitutionnel
Lamelles lipidiques
Microscopie confocale à balayage laser
Peau -- Soins et hygiène
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- OBJECTIVE : Atopic dermatitis (AD) is characterized by compositional and structural changes to the skin at lesional sites. Alteration to the levels and organization of both protein and lipid components are associated with disease status and lead to impaired barrier and hydration. Corneodesmosin (CDSN) and the arrangement and length of the intercellular lipid lamellae (ICLL) are altered in disrupted skin states. The aim of this research was to profile the distribution of CDSN and the ICLL in the stratum corneum (SC) at lesional and non-lesional sites in AD-prone skin and to investigate the impact of an eczema calming lotion containing petroleum jelly, fatty acids, and colloidal oatmeal.
- METHODS : An IRB-approved study was conducted with participants with active AD. From a small subset of participants, tape strips were collected from lesional and non-lesional sites on the arm, prior to and after twice daily application, over 4 weeks of an eczema calming lotion containing petroleum jelly, fatty acids, and colloidal oatmeal. Fluorescent antibody staining was used to investigate the distribution of CDSN. Transmission electron microscopy (TEM) was used to characterize the ICLL.
- RESULTS : The distribution/coverage of CDSN was similar between lesional and non-lesional sites at baseline ; application of the lotion resulted in a more defined honeycomb/peripheral distribution. Normalized ICLL (nICLL) was lower in baseline samples from lesional sites relative to non-lesional sites. Application of the lotion increased this parameter by the end of the study at all sites.
- CONCLUSION : The eczema calming lotion containing petroleum jelly, fatty acids and colloidal oatmeal provided changes in corneodesmosomal proteins distribution and ICLL, consistent with improvements in corneocyte maturation and improved barrier function in the skin of individuals with atopic dermatitis. |
| Note de contenu : |
- MATERIALS AND METHODS : Corneodesmosin staining - Sample preparation for TEM and quantitative analysis of ICLL
- RESULTS : Corneodesmosin distribution |
| DOI : |
https://doi.org/10.1111/ics.12962 |
| En ligne : |
https://drive.google.com/file/d/1M-QgBKcqyi-7NVjWZjqxDYyG3lIJB5xO/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=41351 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 46, N° 4 (08/2024) . - p. 516-525
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Effects of eczema calming lotion on the stratum corneum in atopic dermatitis : Corneodesmosin and intercellular lipid lamellae in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 46, N° 4 (08/2024)
