| Titre : |
Novel peptide acting on both the pre- and post-synaptic pathways |
| Type de document : |
texte imprimé |
| Auteurs : |
Miriam Mateu, Auteur ; Ariadna Grau-Campistany, Auteur ; M. J. Klein, Auteur ; Silvia Pastor, Auteur ; Patricia Carulla, Auteur ; J. A. Boras, Auteur ; Mikel Gorostiaga, Auteur |
| Année de publication : |
2019 |
| Article en page(s) : |
p. 22-26 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge:Antirides
Cosmétiques
Peau -- Soins et hygiène
Peptides
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
An excess of repeated contraction of the muscles involved in facial expressions results in the appearance of fine lines known as expression wrinkles. Neurotransmission that precedes contraction has been widely studied both in the pre-synaptic neuron and its effects on the post-synaptic muscle. Botulinum toxin treatments have lived together with cosmetic ingredients acting in the pre-synaptic or the post-synaptic pathways to relax muscle contraction and improve the fine lines. Here, we present a peptide, born from in silico design, able to work on both the pre- and post-synaptic pathways and on a new protein in the Cosmetics field Munc 18-1. Munapsys efficacy was tested in vivo against a combination of benchmarks covering both pathways. The peptide demonstrated similar or even better results at a lower concentration. |
| Note de contenu : |
- MATERIALS AND METHODS : Munc 18-1/Syntaxin-1 binding assay - Pre-synaptic neurotransmitter release - Post-synaptic gene expression modulation - Calcium mobilization in the sarcoplasm - Myosin quantification - Human neuron-muscle contraction - Double-blind assessment of anti-wrinkles efficacy - Proof-of-concept sad smile
- RESULTS AND DISCUSSION : Munc 18-1/Syntaxin-1 binding assay - Pre-synaptic neurotransmitter release - Post-synaptic gene expression modulation - Calcium mobilization in the sarcoplasm - Myosin quantification - Human neuron-muscle contraction - Double-blind assessment of anti-wrinkles efficacy - Proof-of-concept sad smile |
| En ligne : |
https://drive.google.com/file/d/1WxQyw5Fb6uq3I-hisxcN-t4LbSctjrkb/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=31712 |
in SOFW JOURNAL > Vol. 145, N° 1-2 (01-02/2019) . - p. 22-26
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