| Titre : |
Development of direct contact-killing non-leaching antimicrobial polyurethanes through click chemistry |
| Type de document : |
texte imprimé |
| Auteurs : |
Kaimei Peng, Auteur ; Xuexin Dai, Auteur ; Haili Mao, Auteur ; Hongtao Zou, Auteur ; Zaibo Yang, Auteur ; Weiping Tu, Auteur ; Jianqing Hu, Auteur |
| Année de publication : |
2018 |
| Article en page(s) : |
p. 1239-1250 |
| Note générale : |
Bibliogr. |
| Langues : |
Américain (ame) |
| Catégories : |
Antimicrobiens
BenzisothiazolinoneLa benzisothiazolinone est un biocide très répandu faisant partie du groupe d´isothiazolinone. Utilisé comme agent conservateur dans la peinture, le vernis et l´adhésif, il a un effet fongicide.
Caractérisation
Chimie click
Composés organiques -- Synthèse
Polyuréthanes
Résistance à l'humidité:Résistance à l'eau
Revêtements -- Propriétés thermiques
|
| Index. décimale : |
667.9 Revêtements et enduits |
| Résumé : |
A robust, efficient, and orthogonal click chemistry (copper (I)-catalyzed alkyne-azide cycloaddition) was used to prepare an antimicrobial polymer and precisely control the conjugation ratio of antibiotic molecules to polymer. Antimicrobial polyurethanes with pendant benzisothiazolinone (PU-BIT) were synthesized using click chemistry to connect azide functional polyurethane (PU-N3) and alkyne functional benzisothiazolinone (BIT-Al). The direct contact-killing and non-leaching antimicrobial properties of PU-BIT were verified by both antimicrobial drop and disk diffusion. This approach provides a new methodology and platform for the development of contact-killing and non-leaching antimicrobial materials for a variety of practical applications. This research is the first to demonstrate that the broad-spectrum BIT antibiotic is a selective antibiotic for Gram-positive bacteria when covalently linked to a polymer. PU-BIT film containing 0.8 wt% BIT exhibited a selective antimicrobial performance with bactericidal efficacy of 91.6% and 30% against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, respectively. The mechanism of the selective antimicrobial activity of PU-BIT is also discussed. |
| Note de contenu : |
- MATERIALS AND METHODS : Materials - Synthesis - Characterization
- RESULTS AND DISCUSSION : Monomers and polymers synthesis - Thermal properties - Water-resistance property - Antimicrobial activity |
| DOI : |
10.1007/s11998-018-0068-1 |
| En ligne : |
https://link.springer.com/content/pdf/10.1007%2Fs11998-018-0068-1.pdf |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=31334 |
in JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH > Vol. 15, N° 6 (11/2018) . - p. 1239-1250
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