Antibacterial, anti-keratinized and anti-inflammatory effects of the GMP, a multi-herb extraction on acne vulgaris / Yi-Na Lu in SOFW JOURNAL, Vol. 147, N° 9 (09/2021)  

[article]  inSOFW JOURNAL > Vol. 147, N° 9 (09/2021) . - p. 26-31 Titre : Antibacterial, anti-keratinized and anti-inflammatory effects of the GMP, a multi-herb extraction on acne vulgaris Type de document : texte imprimé Auteurs : Yi-Na Lu, Auteur ; Guang-Yin Wang, Auteur ; Jun Tian, Auteur Année de publication : 2021 Article en page(s) : p. 26-31 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Acné L'acné (nom féminin) est une dermatose (maladie de la peau) inflammatoire des follicules pilosébacés (glandes sécrétant le sébum, à la racine des poils) avec formation de comédons. Cette maladie de la peau est représentée dans sa forme la plus fréquente par l'acné polymorphe juvénile qui touche les adolescents, mais qui ne résume pas toutes les acnés. Il existe aussi des acnés exogènes d'origine professionnelle, médicamenteuse, cosmétique... Anti-inflammatoires Antibactériens Dermo-cosmétologie Kératinisation La kératinisation est la transformation des couches superficielles de la peau (épiderme), ou d'une muqueuse (couche de cellules recouvrant l'intérieur des organes creux en contact avec l'air) qui s'enrichissent progressivement de kératine. Peau -- Soins et hygiène Statistique Index. décimale : 668.5 Parfums et cosmétiques Résumé : Recently reports showed that the pathobiology of acne vulgaris was arising from the exploration of sebaceous gland biology, hormonal factors, hyper-keratinization, and the role of bacteria, sebum, nutrition, cytokines and toll-like receptors (TLRs). Propionibacterium acnes (P. acnes) has a strong proinflammatory activity and targets molecules involved in the innate cutaneous immunity on keratinocytes by acting on TLR-2, leads to the development of comedones. GMP, a multi-herb extraction, targeted most of the major pathogenic features of acne with desired physicochemical traits. It strongly suppressed P. acnes growth, and reduced inflammation by suppressing the TLR-2/NF-κB pathway in SZ-95 sebocytes and HaCaT keratinocytes. GMP exhibited a marginal effect on cell viability and may have modulated hyper-keratinization of the epidermis. These results demonstrate the clinical feasibility of applying GMP for the treatment of acne. Note de contenu : - MATERIALS AND METHODS : Microbial experiments - Cell culture and stimulation - Cell viability test - mRNA expression measurement in HaCaT cells - mRNA expression measurement in SZ-95 cells - ELISA experiments - Statistical analysis - RESULTS : GMP inhibits the growth of P. acnes - GMP promoted the viability of HaCaT cells when stimulated with P. acnes - GMP decreases inflammation induced by P. acnes through the TLR-2 and NF-KB - GMP inhibited the mRNA expression levels related to hyper keratinization En ligne : https://drive.google.com/file/d/1HpLBN6Kcp8YYIvzmLJqBdPHs2cmjfvor/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=36330 [article]

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Correlation between the facial skin microbiome and sensitive skin using the 2bRAD-M technique / Yi-Na Lu in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 46, N° 3 (06/2024)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 46, N° 3 (06/2024) . - p. 414-423 Titre : Correlation between the facial skin microbiome and sensitive skin using the 2bRAD-M technique Type de document : texte imprimé Auteurs : Yi-Na Lu, Auteur ; Lu Cheng, Auteur ; Xue-mei Shi, Auteur Année de publication : 2024 Article en page(s) : p. 414-423 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Dermabacter Microbiome cutané Peau -- Inflammation Sensibilité cutanée Séquençage des acides nucléiques Staphylocoques Index. décimale : 668.5 Parfums et cosmétiques Résumé : - OBJECTIVE : This study aimed to expound on the correlation between facial skin microbiome and sensitive skin (SS) using a novel sequencing technique. - METHODS : We applied the 2bRAD sequencing for the microbiome, which enables accurate characterization of the low-biomass microbiome at species resolution to profile facial skin microbes in SS and non-SS groups. Further, the bacterial colonies were isolated and cultured from skin surfaces to study the pro-inflammatory effect on human keratinocytes by ELISA. - RESULTS : We accordingly identified 1142 genera and 4436 strains. In the SS group, the proportions of Actinomyces and Microbotryomycetes were significantly increased, whereas that of Acidimicrobiia was decreased. Kruskal–Wallis analysis revealed significant differences in 11 genera and 35 species, among which the proportions of Dermabacter, Chryseobacterium, Rhodotorula and Peptoniphilus A were increased in the SS group. Analysis of the top 10 genera revealed increased proportions of Cutibacterium, Corynebacterium and Staphylococcus. Moreover, the proportion of Dermabacter hominis was significantly increased by 18.9-fold in the SS group, whereas those of many Streptococcus strains were significantly decreased. Focus on the isolated bacterial colonies from skin surfaces, more yellow colonies were found in SS group when cultured in Tryptic Soy Broth medium for 48 h, and more interleukin-8 was detected on keratinocytes after yellow colonies stimulation, such as S.capitis, M.luteus. - CONCLUSIONS : This study suggests that more SS-associated microorganisms can be identified using the 2bRAD technique even with a small sample size. Dermabacter hominis and Chryseobacterium was firstly reported with a significantly increase in SS, and the S.capitis, as well as M.luteus, but not S.aureus, may be associated with skin inflammation. Note de contenu : - MATERIALS AND METHODS : Participant recruitment - Measurement of skin parameters - Sample collection - Bacteria isolation, culture and stimulation - Statistical analysis - RESULTS : Skin parameters of the participants - Analysis of the skin microbiome - Comparison of the genera and species of skin microbiome between the two groups - The changes of bacterial colonies in SS group DOI : https://doi.org/10.1111/ics.12941 En ligne : https://drive.google.com/file/d/1x4VzbOtDEJWXrFFvRBQyS0IR_O5LeilW/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=41343 [article]

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Promoting effect of a gene expression related moisturizer on skin hydration and barrier function / Yi-Na Lu in SOFW JOURNAL, Vol. 144, N° 9 (09/2018)  

[article]  inSOFW JOURNAL > Vol. 144, N° 9 (09/2018) . - p. 28-32 Titre : Promoting effect of a gene expression related moisturizer on skin hydration and barrier function Type de document : texte imprimé Auteurs : Yi-Na Lu, Auteur ; Ya-Di Yang, Auteur ; Zhi-Yong Xie ; Jun Tian Année de publication : 2018 Article en page(s) : p. 28-32 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Barrière cutanée Cosmétiques Expression génique Peau -- Soins et hygiène Produits hydratants Index. décimale : 668.5 Parfums et cosmétiques Résumé : The moisturizing performance of Gmoist® Sea-Gel was evaluated based-upon 14 healthy volunteers. It was found that skin moisture content markedly increased and TEWL effectively decreased after Gmoist® Sea-Gel applied for 7d. Then using real-time fluorescence quantitative PCR technology, HaCaT cells were cultured with Gmoist® Sea-Gel to study six genes ex¬pression level related to skin hydration and barrier function. Results showed Gmoist® Sea-Gel significantly promoted the INV, TG-1, FLG and CASP-14 mRNA's expression after 24 hour's treatment. Gmoist® Sea-Gel can upregulate cornified cell envelope related genes expression, promote the degradation of filaggrin into natural moisturizing factors to strengthen skin hydration and barrier function. Note de contenu : - In vivo studies - Cell viability test - Gene expression measurement - Gmoist Sea-Gel increased the CM and reduced the TEWL - HaCaT cell toxicity of Gmoist Sea-Gel - Gmoist Sea-Gel regulated the CE formation related gene expression - Gmoist Sea-Gel promoted the FLG degradation - Gmoist Sea-Gel slightly upregulated AQP-3 gene expression En ligne : https://drive.google.com/file/d/1jKk5IrgdBk7as-IStqhBFFLX9mav1AMs/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=30956 [article]

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