[article]
| Titre : |
A stable and standardized aloe vera gel extract with proven efficacy in oral and personal care applications |
| Type de document : |
texte imprimé |
| Auteurs : |
Avani Mainkar, Auteur ; Debajyoti Mukherjee, Auteur ; Anuja Tabrej, Auteur ; Kedar Vaze, Auteur ; Pranjali Dhawal, Auteur |
| Année de publication : |
2023 |
| Article en page(s) : |
p. 10-13 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Aloe vera et constituants
Anti-inflammatoires
Bouche -- Soins et hygiène
Cicatrisation
Cosmétiques -- Stabilité
Dermo-cosmétologie
Gels -- Emploi en cosmétologie
Peau -- Soins et hygiène
Produits d'hygiène bucco-dentaire
Produits hydratants
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : Research evidence supports the skin benefits of Aloe gel in moisturization and healing. However, the market is fraught with aloe gel that is unstandardized, unstable, or unsafe to use. Thus, it is necessary to provide an aloe gel extract that is safe and stable with demonstrated efficacy. In the present study, AloeHealâ„¢, a stable and standardized, Aloe vera gel extract was developed and tested for its performance in both skincare and oral care applications.
- Methods : Aloe vera gel, AloeHealâ„¢ with 0.16% mucopolysaccharide and 0.27% total solid content was extracted by a proprietary mild extraction method. It was further tested for stability (ICH guidelines) and preservative challenge test, PCT, (USP51). The cell proliferative activity, reduction in lipopolysaccharide (LPS)-induced IL-6, and wound healing efficiency were studied in both human gingival fibroblast (HGF) and human dermal fibroblasts (HDF). Finally, AloeHealâ„¢ was evaluated for skin moisturization in a pilot trial (6 volunteers) using Corneometer.
- Results : Stability results of AloeHealâ„¢ showed no hydrolysis leading to free sugars. The extract also passed the PCT. In the cell proliferation assay, highest activity was observed at 0.5 mg/ml in both HGF (134.87%) and HDF (142.47%) cells. In addition, at this concentration, 100% wound healing activity was observed in both cell types. AloeHealâ„¢ also showed potent anti-IL-6 activity in HGF (IC50=0.111mg/ml) and HDF (IC50=0.430mg/ml) cell lines. In the pilot in vivo moisturizing study AloeHealâ„¢ retained significant skin moisture for 2 hours as compared to the placebo.
- Conclusion: AloeHealâ„¢ is a stable, safe, and efficacious extract of Aloe vera gel with proven skin moisturizing, wound healing, anti-inflammatory, oral-care, and skin rejuvenating ability. |
| Note de contenu : |
- MATERIALS AND METHODS : Preparation of AloeHeal TM - Testing for stability and preservative efficacy - Cell proliferative capacity - Wound healing assay - Anti-inflammation assay - Pilot study for skin moisturization in human volunteers
- RESULTS : Stability and preservative efficacy test - Cell proliferation assay - Wound healing assay - Anti-inflammatory assay - Skin moisturization ability in human volunteers - A pilot study
- Table 1 : Results of stability studies for AloeHeal TM
- Table 2 : Result of PCT for AloeHeal TM |
| En ligne : |
https://drive.google.com/file/d/1Z0A_Mg1X50z4LflM_DzxzUv9NTk1jdLu/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=39819 |
in SOFW JOURNAL > Vol. 149, N° 7/8 (07-08/2023) . - p. 10-13
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A stable and standardized aloe vera gel extract with proven efficacy in oral and personal care applications in SOFW JOURNAL, Vol. 149, N° 7/8 (07-08/2023)
