| Résumé : |
A desorption system in equilibrium at constant total volume is con-sidered, consisting of a solid porous complex loaded with an extractable component and immersed in a solvent for this component. Although subject to the Nernst's distribution law, the partition coefficient is influenced by sorptive forces. Thus the concentration of component-solute in the pore volume is always greater than in the external volume of extract. The coefficient functions therefore as a retention coefficient, which, furthermore, reaches a maximum at a volume varying with the state of subdivision of the porous complex.
This maximum, denoted K(max), is, however, characteristic, neces-sarily within its region of inherent nonisomorphism. The actual experi-mental data of the hydrion portion of the solute follow an exponential law of release, leading to a new concept, "dpH," representing the maximum concentration of hydrions extractable as the pH of the "clinging" layer, which is the liquid filling the pores to saturation without dripping away from the solid adsorbendum.
Whatever desorption system is chosen for the sample tested, its K(max), with dpH exponentially linked to it, symbolizes its physical architecture with a possible bearing on organic deterioration, say to fibrillar-rot or pus. Collagen with its marked nonisotropism is an ideal adsorbendum once it is "fixed," for the genesis of new ideas, say on cellular-transport function. Accordingly, having regard to location, e.g., shoulder, flank, etc., and incidence of any ohserved abnormalities in K(max) and dpH values, studies here suggest correlation with growth phenomena.
For all biological samples, such as surgical tissue in pathological work with little or no swelling left of their molecular structures, physical architecture offers a new diagnostic technique of high accuracy for the early detection of growth into tumors, benign or cancerous or intermediately. |
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Desorption in porous complexes and its applicability to particle growth in JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA), Vol. LXXII (Année 1977)
