Determination of cyclic volatile methylsiloxanes in personal care products by gas chromatography / Herbert M. Brothers in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 39, N° 6 (12/2017)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 39, N° 6 (12/2017) . - p. 580-588 Titre : Determination of cyclic volatile methylsiloxanes in personal care products by gas chromatography Type de document : texte imprimé Auteurs : Herbert M. Brothers, Auteur ; T. Boehmer, Auteur ; R. A. Campbell, Auteur ; S. Dorn, Auteur ; J. J. Kerbleski, Auteur ; S. Lewis, Auteur ; C. Mund, Auteur ; D. Pero, Auteur ; K. Saito, Auteur ; M. Wieser, Auteur ; W. Zoller, Auteur Année de publication : 2017 Article en page(s) : p. 580-588 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Chromatographie en phase gazeuse Cosmétiques Cosmétiques -- Analyse Organosilicones shampooings Silicones -- Emploi en cosmétologie Index. décimale : 668.5 Parfums et cosmétiques Résumé : Objective : Organosiloxanes are prevalent in personal care products (PCPs) due to the desired properties they impart in the usage and application of such products. However, the European Chemical Agency (ECHA) has recently published restriction proposals on the amount of two cyclic siloxanes, octamethylcyclotetrasiloxane (D4) and decamethylcyclotetrasiloxane (D5), allowed in wash off products such as shampoos and conditioners which are discharged down the drain during consumer use. This legislation will require that reliable analytical methods are available for manufacturers and government agencies to use in documenting compliance with the restrictions. This article proposes a simple analytical method to enable accurate measurement of these compounds down to the circa 0.1 weight per cent level in PCPs. Methods : Although gas chromatography methods are reported in the literature for quantitation of D4 and D5 in several matrices including PCPs, the potential for generation of false positives due to contamination, co-elution and in situ generation of cyclic volatile methylsiloxanes (cVMS) is always present and needs to be controlled. This report demonstrates the applicability of using a combination of emulsion break, liquid–liquid extraction and silylation sample preparation followed by GC-FID analysis as a suitable means of analysing PCPs for specific cVMS. Results : The reliability and limitations of such methodology were demonstrated through several round-robin studies conducted in the laboratories of a consortium of silicone manufacturers. In addition, this report presents examples of false positives encountered during development of the method and presents a comparative analysis between this method and a published QuEChERS sample preparation procedure to illustrate the potential for generation of false positives when an inappropriate approach is applied to determination of cVMS in personal care products. Conclusion : This report demonstrates that an approach to determine cVMS levels in personal care products is to perform an emulsion break on the sample, isolate the non-polar phase from the emulsion break and treat with a silylation reagent to abate potential in situ formation of cyclics during the course of GC-FID analysis. Round-robin studies conducted in laboratories representing multiple siloxane manufacturers demonstrated the reliability of the GC-FID method when measuring cVMS in PCPs down to circa 0.1%. Note de contenu : - MATERIALS AND METHODS : GC method - Chemicals - Materials - Gas chromatograph - GC method and sample preparation - Calibration - Inter-laboratory round-robin studies - Preparation of shampoo and conditioner lab formulation samples - Commercially available personal care product samples - Additional sample preparations and analysis by GC-MS - RESULTS AND DISCUSSION : Round-robin analysis of laboratory formulations and commercially available personal care products - Considerations regarding analysis of cVMS in personal care products - Potential for thermal degradation in GC - Potential for interferences - Impact of sample preparation on chromatography - Impact of sample preparation on false positives DOI : 10.1111/ics.12411 En ligne : http://onlinelibrary.wiley.com/doi/10.1111/ics.12411 Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=29468 [article]

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