| Titre : |
Mitophagy activation - a novel anti-ageing cosmetic target |
| Type de document : |
texte imprimé |
| Auteurs : |
Emilio Rubio, Auteur ; Miguel Perez-Aso, Auteur ; Jordi Bosch, Auteur ; Ricard Armengol, Auteur ; Blanca Martinez-Teipel, Auteur ; Hagen Döring, Auteur ; Esther Seco, Auteur ; Ana Serrano-Puebla, Auteur ; Patricia Boya, Auteur |
| Année de publication : |
2017 |
| Article en page(s) : |
p. 2-9 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge
Dermo-cosmétologie
Mitophagie
Peau -- Soins et hygiène
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Mitophagy is a selective quality control process that targets and degrades damaged mitochondria. Mitophagy is impaired with age, contributing to mitochondrial and cellular dysfunction. Therefore, we hypothesized that boosting mitophagy would keep oxidative toxicity in check and recover function in aged skin cells, thus leading to a visible rejuvenation effect in vivo.
Compounds were screened for mitophagy in SH-SY5Y cells with a nove] flow cytometry-based approach. We identified a combination of Paeoniflorin and Trehalose (PF/TH) that synergisticaily induced mitochondrial renewal through mitophagy activation. This activity was confirmed in Normal Human Dermal Fibroblasts (NHDF). A set of assays on NHDF and senescent human dermal fibroblasts were designed to explore cellular responses to mitophagy activation by PF/TH. Our results revealed an anti-ageing activity profile, via restoring collagen to levels found in young cells and reversing other characteristic ageing signs : ATP decrease, MMP-1 release and 8-galactosidase positive cells. Fibroblasts also became more resilient towards mitochondrial damage and oxidative stress, as showed by insults with CCCP and pyrogallol. Finally, a clinical study on aged volunteers confirmed rejuvenating effects achieved by FP/TH active. These results support mitophagy activation as a target for cosmetic anti-ageing applications. |
| Note de contenu : |
- EXPERIMENTAL : In vitro studies - Clinical study
- RESULTS : Mitochondrial recycling : mitophagy - Mitochondrial quality : mitochondrial membrane potential - Mitochondrial function AT° - Oxidative stress - Senescence in ageing models - Ageing markers - In vivo rejuvenating effects |
| En ligne : |
https://drive.google.com/file/d/1_B4ZN6mvGEsUbrczqA5DjXlEoyp-ZKT2/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=28726 |
in SOFW JOURNAL > Vol. 143, N° 6 (06/2017) . - p. 2-9
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