[article]
| Titre : |
Ascorbic acid 2-glucoside : An ascorbic acid pro-drug with longer-term antioxidant efficacy in skin |
| Type de document : |
document électronique |
| Auteurs : |
Carine Jacques, Auteur ; Camille Génies, Auteur ; Daniel Bacqueville, Auteur ; Amélie Tourette, Auteur ; Nathalie Borotra, Auteur ; Fernanda Chaves, Auteur ; Fabio Sanches, Auteur ; Anne L. Gaudry, Auteur ; Sandrine Bessou-Touya, Auteur ; Hèlène Duplan, Auteur |
| Année de publication : |
2021 |
| Article en page(s) : |
p. 691-702 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Acide ascorbique glucoside
Antioxydants
Dermo-cosmétologie
Explant de peau
Formulation (Génie chimique)
Ingrédients cosmétiques
Peau -- Soins et hygiène
Peau humaine
Protection cutanée
Systèmes de livraison (pharmacie)
Vitamine C
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : Deleterious effects of pollutants and ultraviolet radiation on the skin can be attenuated using formulations containing antioxidants. However, these have disadvantages, including chemical instability, photodegradation, poor bioavailability or biological activity. Here, two commercial formulations were evaluated: one optimized to stabilize and deliver ascorbic acid (AA) at 15% and the other containing a glucoside form of AA, namely ascorbic acid 2-glucoside (AA2G), at 1.8% and at a physiological pH. We compared the skin delivery, antioxidative effects and chemical stability of AA2G with AA in their respective formulations.
- Methods : Skin delivery was measured using fresh viable human skin explants, and oxidative stress was measured using a human reconstructed epidermal (RHE) model according to levels of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase.
- Results : Ascorbic acid 2-glucoside was completely metabolized to AA by the skin before entering the receptor compartment. The skin contained parent and AA, indicating a reserve of AA2G was present for further metabolism. For AA2G and AA, maximum flux of AA-equivalents was at 12 h, with continued absorption over 24 h. The absolute amount in µg was higher in the skin after application of AA than after application of AA2G. This may suggest a greater antioxidative effect; however, according to all three measurements of oxidative stress, the protective effect of AA and AA2G was similar. Unlike AA, AA2G was chemically stable under storage conditions.
- Conclusion : A lower concentration of AA2G is as effective as the active metabolite, AA, in terms of antioxidant effects. AA2G was chemically stable and can be applied at a lower concentration than AA, thus avoiding the need for an acidic formulation with a pH below 3.5. |
| Note de contenu : |
- MATERIALS AND METHODS : Materials - Storage stability - Penetration and metabolism in viable fresh human skin explants - HPLC/UV analysis of AA and AA2G - Measurement of oxidative stress and antioxidant response - Data handling and analyses
- RESULTS : Stability of AA2G and AA in formulations - Prodrug concept: AA release in fresh viable human skin explants from AA2G - Kinetic of penetration of AA2G vs. AA formulations in fresh viable human skin explants - Antioxidant protection of AA2G in RHE model |
| DOI : |
https://doi.org/10.1111/ics.12745 |
| En ligne : |
https://drive.google.com/file/d/1jBKOIM98kz6UIcCT2A28dTue6JagkvCH/view?usp=shari [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=37050 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° 6 (12/2021) . - p. 691-702
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Ascorbic acid 2-glucoside : An ascorbic acid pro-drug with longer-term antioxidant efficacy in skin in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° 6 (12/2021)
