| Titre : |
Key mechanisms for new era of personalised cosmetics |
| Type de document : |
texte imprimé |
| Auteurs : |
Salvador Mena-Molà , Auteur ; José Luis GarcÃa-Giménez, Auteur ; Daymé Gonzalez-RodrÃguez, Auteur ; Pablo Soro-Barrio, Auteur ; Lidia Roselló, Auteur ; Pascual Cuadrado-Escamilla, Auteur |
| Année de publication : |
2017 |
| Article en page(s) : |
p. 77-81 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge
EpigénétiqueL'épigénétique (mot-valise de "épigenèse" et "génétique") est la discipline de la biologie qui étudie la nature des mécanismes modifiant de manière réversible, transmissible (lors des divisions cellulaires) et adaptative l'expression des gènes sans en changer la séquence nucléotidique (ADN)
"Alors que la génétique correspond à l'étude des gènes, l'épigénétique s’intéresse à une "couche" d’informations complémentaires qui définit comment ces gènes vont être utilisés par une cellule ou… ne pas l'être".
"C'est un concept qui dément en partie la "fatalité" des gènes".
Peau -- Soins et hygiène
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Ageing is one of the unavoidable processes in life and can be defined as changes in structures and tissue processes that affect related organs and systems with time.
We know that the environment and our relation with it can accelerate or delay cell ageing. Epigenetics helps us to understand how some genes involved in cell senescence, protection mechanisms and cell detoxication, and even the genes that participate in stem cell renovation, are regulated by processes based on DNA methylation, post-translational histone modifications and non coding RNAs (microRNAs and IncRNAs). Several studies have confirmed that cell ageing can be delayed, and even reversed, by epigenetic reprogramming. Evidently this discipline opens up endless possibilities for designing new anti-ageing strategies.
The present article explains some ageing-related epigenetic mechanisms and how these mechanisms are a key element to consider in skin care and health. Finally, the potential that this discipline has on the generation and characterisation of new anti-ageing cosmetic active principles is described. |
| Note de contenu : |
- EPIGENETIC DEREGULATION : Telomere shortening - Stem cell exhaustion - Cell senescence
- MICRORNAS AS KEY MODULATORS OF CELL AGEING
- EPIGENETICS AND ITS POTENTIAL USE IN ANTI-AGEING COSMETIC TREATMENTS
- FIGURES : 1. the nine hall marks of ageing and main epigenetic mechanisms involved - 2. Epigenetic mechanisms that participate in the control of genetic regulation during ageing. a) Chromatin remodeling during cellular ageing ; b) global epigenetic changes at DNA methylation and histone level during ageing ; c) telomere attrition mediated by deregulation of epigenetic marks and epigenetic machinery
- TABLES : 1. Global epigenetic changes associated to cellular ageing - 2. miRNAs participating in the regulation of pathways associated to 9 hallmarks of ageing. miRNAs has been listed from works of LW Harries and XM Caravia |
| En ligne : |
https://drive.google.com/file/d/1qx2ES6G9x6xvo85Fwu_pZuDcprJnZ_SS/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=28342 |
in PERSONAL CARE EUROPE > Vol. 11, N° 2 (04/2017) . - p. 77-81
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