| Titre : |
Immune balance rating system applied to sunscreens |
| Type de document : |
texte imprimé |
| Auteurs : |
Bryce Feltis, Auteur ; Grace Guo, Auteur ; Brent Baxter, Auteur |
| Année de publication : |
2017 |
| Article en page(s) : |
p. 65-70 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Cellules -- Cultures et milieux de culture
Etude in vitro
Evaluation
Produits antisolaires
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
The Immune Balance Rating- (IBR) system is an exciting new in vitro testing protocol for sunscreens and other topical products based upon cellular responses from skin and immune tells. The system compares products to a reference standard and measures five cellular outputs. Each output gives a relative rating and the product is then scored based on the average across all areas. This allows standardised grading of products and more substantive claims and targeted marketing.
The testing protocols involve cell culture of human skin keratinocytes and monocytes. Cells were tested for viability, cytokine and reactive oxygen production alter co-exposure with product and UV light. All exposures were 24 hours over a range of concentrations.
We have tested six commercial SPF 50+ sunscreen formulations, each of identical base components, but varying in active component concentrations and preservatives. The standard formulations contained 27% active ingredients, whereas the low active formations contained 15% total actives. The preservatives tested were capyrlyl glycol, MIT or parabens.
Based on the aggregate IBR scores, all 3 low active formulations rated higher than the standard formulations. Preservative type had a small effect, most noticeable in the low active formulations.
The IBR system has shown the first in vitro evidence that low active sunscreens are less reactive than standard formulation sunscreens to human skin and immune tells.
This demonstrates that the is a valuable tool that can differentiate between very similar products. lt allows further support of claims around sensitive skin with reproducible scientific data. |
| Note de contenu : |
- METHODS : Product specifications - Product preparation - Cell culture - Product and UV exposure - Cell viability testing - Cytokine response testing - Reactive oxygen species testing - Rating and scoring
- RESULTS : Abbreviations used in figures - Cytotoxicity - IBR1 : Immunostimulation - IBR2 : Immunosuppression - IB3 : Phototoxicity - IBR4 : Protection from UVB - IBR5 : Protection from UVA - Summary and overall scoring
- TABLES : 1. Summarised scoring table for all 6 sunscreen formulations across the 5 IBR tests. The final score is the average of all tests - 2. IBR claims matrix. Claims can be made based upon an individual rating in a test category or the average overall rating |
| En ligne : |
https://drive.google.com/file/d/1t8hHEnRx0FQAnFGEkfZno6fV2AS0oA85/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=28340 |
in PERSONAL CARE EUROPE > Vol. 11, N° 2 (04/2017) . - p. 65-70
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