| Titre : |
Antioxidants - What is their significance in sun protection ? |
| Type de document : |
texte imprimé |
| Auteurs : |
Michael W. Brown, Auteur ; L. G. Hamilton, Auteur ; S. P. Long, Auteur |
| Année de publication : |
2003 |
| Article en page(s) : |
p. 2-12 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
ADN -- Altération
Antioxydants
Etude in vitro
Etude in vivo
Facteur de protection solaire
Lipides
Peau -- Soins et hygiène
Photo-oxydation
Produits antisolaires
Radicaux libres (chimie)
Rayonnement ultraviolet -- Effets physiologiques
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
It has long been known that ultraviolet (UV) light can interact directly with biological chromaphores such as deoxyribonucleaic acid (DNA) and in so doing, can damage those molecules. More recently the role of UV-light in the generation of free radicals in the skin has suggested a secondary indirect route for biological damage. Here, we describe a series of in vitro, ex vivo and in vivo experiments designed to investigate whether certain antioxidant materials are able to prevent free radical initiated damage to biological molecules during exposure to UV-light. A number of antioxidant materials are shown to be effective at preventing DNA damage (measured by alkaline comet assay) in a tissue culture model and at preventing lipid peroxidation in both an in vitro model and ex vivo human stratum corneum tape stripping model. The performance of these materials when used in combination can show a synergistic or optimised effect. However when antioxidant materials proven to be effective at preventing DNA damage and lipid peroxidation are incorporated into a sunscreen product, no effect is measurable on the sun protection factor (SPF) on the product. |
| Note de contenu : |
- In vitro investigations
- Ex vivo investigations
- In vivo investigations |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=28139 |
in SOFW JOURNAL > Vol. 129, N° 7 (07/2003) . - p. 2-12
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