Poly(N-acryloyl ciprofloxacin-co-acrylic acid)-incorporated waterborne polyurethane leather coating with long-lasting antimicrobial property / Jinming Chang in JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA), Vol. CXII, N° 1 (01/2017)  

[article]  inJOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA) > Vol. CXII, N° 1 (01/2017) . - p. 15-22 Titre : Poly(N-acryloyl ciprofloxacin-co-acrylic acid)-incorporated waterborne polyurethane leather coating with long-lasting antimicrobial property Type de document : texte imprimé Auteurs : Jinming Chang, Auteur ; Gaofu Yang, Auteur ; Qi Zeng, Auteur ; Zhonghui Wang, Auteur ; Zhou Xu, Auteur ; Yi Chen, Auteur Année de publication : 2017 Article en page(s) : p. 15-22 Note générale : Bibliogr. Langues : Américain (ame) Catégories : Antimicrobiens Copolymères -- Synthèse Croûte (cuir) On entend par "cuir en croûte" des cuirs ayant subi les opérations jusqu'au tannage, à l'exclusion de toute opération de corroyage ou de finissage, mais qui, par opposition aux wet-blue ont été séchés. Cuirs et peaux -- Finition Polymères -- Synthèse Polymères en émulsion Polyuréthanes Index. décimale : 675 Technologie du cuir et de la fourrure Résumé : o overcome the leaching problem associated with low-molecular-weight antimicrobial agents, a water soluble antimicrobial polymer, poly(N-acryloyl ciprofloxacin-co-acrylic acid), was designed and synthesized via acryloylation of the secondary amine in 7-piperazinyl substituent of ciprofloxacin and subsequent copolymerization with acrylic acid. The structure of the copolymer was characterized by 1H nuclear magnetic resonance (NMR), Fourier transform infrared (FTIR) spectra, X-ray photoelectron spectroscopy (XPS), and gel permeation chromatography (GPC). The copolymer was compatible with waterborne polyurethane for leather finishing, and remained antimicrobial even though the parent structure of ciprofloxacin molecule was altered. When incorporated into waterborne polyurethane leather coating as an antimicrobial agent, poly(N-acryloyl ciprofloxacin-co-acrylic acid) proved seldom leached out from the coating even after being rinsed for ten times. Based on these results, the water soluble antimicrobial copolymer designed in this study may prevent depletion of antimicrobial function of waterborne polyurethane leather coating, extending the lifetime of the leather products and enhancing their hygiene properties. Note de contenu : - Materials - Preparation of N-acryloyl ciprofloxacin (NACPF) - Synthesis of Poly(N-acryloyl ciprofloxacin-co-acrylic acid) - Characterization of Poly(NACPF)-co-AA) - Crust leather finishing by Poly(NACPF)-co-AA) incorporated WPU - Scanning Electron Microscope (SEM) observatin - Bactericidal test - Statistics En ligne : https://drive.google.com/file/d/123bCchShzKFoVumI-TtZ60-U7yV0pE91/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=27565 [article]

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Thermally responsive collagen switching from bactericidal for ambient storage condition to biologically inert in vivo / Jinming Chang in JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA), Vol. CXIII, N° 4 (04/2018)  

[article]  inJOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA) > Vol. CXIII, N° 4 (04/2018) . - p. 114-121 Titre : Thermally responsive collagen switching from bactericidal for ambient storage condition to biologically inert in vivo Type de document : texte imprimé Auteurs : Jinming Chang, Auteur ; Zhou Xu, Auteur ; Gaofu Yang, Auteur ; Zhonghui Wang, Auteur ; Yi Chen, Auteur ; Haojun Fan, Auteur Année de publication : 2018 Article en page(s) : p. 114-121 Note générale : Bibliogr. Langues : Américain (ame) Catégories : Antimicrobiens Collagène -- Conservation Composés organiques -- Synthèse Poly(n-isopropylacrylamide) Index. décimale : 675 Technologie du cuir et de la fourrure Résumé : Incorporating preservatives is now the most commonly employed strategy to prevent microbial deterioration of collagen. However, many preservatives are non-selective; they cannot differentiate the orthologs in mammalian cells from their biological targets in pathogens, and thus their incorporation compromises the inherent biocompatibility of naturally occurring collagen. Here, we report a strategy to covalently anchor antibacterial agents to collagen via a thermally responsive poly(N-isopropylacrylamide) spacer. As the spacer suddenly collapses from an extended coil upon heating through ~30°C, bioactivity of the anchored antibacterial agents can be switched off, because their lateral mobility and, hence, target-site accessibility are restricted. Accordingly, the modified collagen can be preserved without microbial deterioration for ambient storage condition, while imposing no cytotoxic impact upon surrounding tissues in vivo. This thermally responsive collagen holds great potential in biomedical fields, where the collagen products are intended to have intimate contact with human tissues or be administered parenterally. Note de contenu : - Materials - Synthesis of NHS ester-activated RAFT agent - Synthesis of N-acryloyl ciprofloxacin - Synthesis of PNIPAM-ciprofloxacin conjugate - Covalent anchoring of PNIPAM-ciprofloxacin conjugate onto collage - Characterization En ligne : https://drive.google.com/file/d/1tQt8XtEUmJ7NxBB2IyUcepNHuJXcEXyK/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=30340 [article]

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