| Titre : |
A comparison of biological activities of a new soya biopeptide studied in an in vitro skin equivalent model and human volunteers |
| Type de document : |
texte imprimé |
| Auteurs : |
Valérie André-Frei, Auteur ; E. Perrier, Auteur ; C. Augustin, Auteur ; O. Damour, Auteur ; P. Bordat, Auteur ; K. Schumann, Auteur ; Thomas Förster, Auteur ; Marianne Waldmann-Laue, Auteur |
| Année de publication : |
1999 |
| Article en page(s) : |
p. 299–311 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Tags : |
'Modèle équivalent de peau' 'Etude in vivo' 'Matrice extracellulaire' Synthèse Peptide |
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
During aging, the epidermis and dermis become thin and an efficient anti-aging product should be able to stimulate the metabolism of senescent fibroblast and keratinocytes, in order to increase the quantity of extra-cellular matrix components such as collagen and glycosaminoglycans. A study performed in parallel on an in vitro skin equivalent model, and in vivo, with human volunteers, demonstrated the efficacy of one specific soya biopeptide for anti-aging properties.
Such a biopeptide induces a significant increase of glycosaminoglycans synthesis in vitro and in vivo after a one-month treatment. We also showed that this new cosmetic ingredient is able to stimulate favourably the collagen synthesis in vitro and in vivo.
This study provided the proof for anti-aging properties of a new soya biopeptide and also validated the skin equivalent model developed for this experimentation as an alternative method to animal or human testing for some cosmetic efficacy evaluations. |
| DOI : |
10.1046/j.1467-2494.1999.211929.x |
| En ligne : |
https://onlinelibrary.wiley.com/doi/10.1046/j.1467-2494.1999.211929.x |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=26475 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 21, N° 5 (10/1999) . - p. 299–311
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