| Titre : |
Leachable pegylated cellulose acetate complex: a promising approach for controlled porosity osmotic pump tablets of Captopril |
| Type de document : |
texte imprimé |
| Auteurs : |
Muhammad Faheem Akhtar, Auteur ; Muhammad Hanif, Auteur |
| Année de publication : |
2020 |
| Article en page(s) : |
p. 439-446 |
| Note générale : |
Bibliogr. |
| Langues : |
Américain (ame) |
| Catégories : |
Acétate de cellulose L'acétate de cellulose est une matière plastique inventée en 1865. C'est l'ester acétate de la cellulose.
Comprimés
Formulation (Génie chimique)
Osmolalité
Polyéthylène glycol
Sorbitol
|
| Index. décimale : |
667.9 Revêtements et enduits |
| Résumé : |
The aim of the present study was to develop pegylated cellulose acetate coating layer having leachable membrane created by controlled porosity osmotic pump (CPOP) technique. Already optimized core tablets of Captopril were used for the application of CPOP. In Box–Behnken design, cellulose acetate, polyethylene glycol, and sorbitol were used as variables and %Captopril release as a response for the coating process. Formulations were characterized by weight gain, thickness of leachable membrane, content uniformity, drug release, pH, dissolution medium osmolality effect, FTIR, and stability analysis for the optimization purpose. Optimized formulation was within the pharmacopoeial limits. Observed weight gain was 4.38–6.97%, and thickness of leachable membrane was 1.24–1.47 mm. Content uniformity was found to be 91.65–99.61%. Phosphate buffer of pH 6.8 showed 86.22–92.79% drug release and the first-order release pattern. pH-independent but osmolality-dependent drug release was observed. No incompatibility between the ingredients of prepared dosage form was observed in FTIR analysis. Accelerated stability study for 6 months showed no significant change in the prepared dosage form. Conclusively, prepared CPOP tablets can be used for the controlled release of Captopril in hypertensive patients to maintain the desired drug concentration within the body for required time period. |
| Note de contenu : |
- MATERIALS AND METHODS : Materials
- METHODS : Experimental design - Formulation of CPOP tablets - Physical evaluation of CPOP tablets - Content uniformity - Drug release kinetics - effect of dissolution medium osmolaty on %captopril release - Effect of pH on %captopril release - FTIR spectroscopic analysis - Stability study statistical analysis
- RESULTS AND DISCUSSION : Physicochemical process of CPOP tablets - Content uniformity of CPOP tablets - Drug release kinetics for CPOP tablets - Effect of dissolution medium osmolality on %captopril relase - Effect of pH on %captopril release - FTIR spectroscopic analysis - Stability study |
| DOI : |
https://doi.org/10.1007/s11998-019-00290-7 |
| En ligne : |
https://link.springer.com/content/pdf/10.1007/s11998-019-00290-7.pdf |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33994 |
in JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH > Vol. 17, N° 2 (03/2020) . - p. 439-446
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Leachable pegylated cellulose acetate complex: a promising approach for controlled porosity osmotic pump tablets of Captopril in JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH, Vol. 17, N° 2 (03/2020)
