| Titre : |
Clearing senescent cells for rejuvenated skin |
| Type de document : |
texte imprimé |
| Auteurs : |
Franziska Wandrey, Auteur ; Daniel Schmid, Auteur ; Fred Zülli, Auteur |
| Année de publication : |
2020 |
| Article en page(s) : |
p. 144-146 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge
Carbonylation
Dermo-cosmétologie
Extraits de plantes:Extraits (pharmacie)
Fibroblastes
Peau -- Soins et hygiène
Protéines
Régénération (biologie)
Vieillissement
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Cellular senescence is one of the hallmarks of ageing. Senescent cells that reside in the dermis as a result of the ageing process and oxidative stress, secrete pro-inflammatory factors that further contribute to ageing.
Therefore, eliminating senescent cells has emerged as a promising anti-ageing therapy in the medical field in the past few years. This novel concept known as ‘senolytics’ helps to clear tissues of senescent cells without affecting healthy cells in order to reduce inflammation and rejuvenate the tissue. For the first time, this concept has been adapted for cosmetics. An extract from organic alpine rose leaves demonstrated a clear senolytic activity on senescent fibroblasts. In placebo-controlled clinical studies, the alpine rose extract prevented the formation of protein carbonyls, one of the most harmful irreversible modifications of proteins, upon UVA irradiation. In addition, treatment with alpine rose extract significantly reduced skin redness and increased elasticity. |
| Note de contenu : |
- Senolytic drugs to promote longevity
- Protein carbonylation
- An extract from organic Swiss alpine rose leaves
- Materials and methods : Senolytic assay - In vivo protein carbonylation assay - Clinical anti-ageing study
- Results and discussion : Alpine rose extract has senolytic activity - Alpine rose extract prevents protein carbonylation - Increase in skin elasticity and decrease in redness |
| En ligne : |
https://drive.google.com/file/d/1RHJdbDdfywG1ehP1WKEgEq-6J2D9scxo/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33964 |
in PERSONAL CARE EUROPE > Vol. 14, N° 2 (04/2020) . - p. 144-146
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Clearing senescent cells for rejuvenated skin in PERSONAL CARE EUROPE, Vol. 14, N° 2 (04/2020)
