[article]
| Titre : |
3D-Printed Franz cells – update on optimization of manufacture and evaluation |
| Type de document : |
document électronique |
| Auteurs : |
Bruno C. Sil, Auteur ; R. G. Belgrave, Auteur ; M. P. Alvarez, Auteur ; L. Luo, Auteur ; M. Cristofoli, Auteur ; M. R. Penny, Auteur ; David J. Moore, Auteur ; Jonathan Hadgraft, Auteur ; S. T. Hilton, Auteur ; Majella E. Lane, Auteur |
| Année de publication : |
2020 |
| Article en page(s) : |
p. 415-419 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Etude in vitro
Franz, Cellules de
Impression tridimensionnelle
Microscopie électronique à balayage
Perméation
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Objectives : Laboratory in vitro permeation processes require the use of modified Franz type diffusion cells which are conventionally fabricated from glass. Fragility and high cost are frequently associated with this type of laboratory apparatus. The purpose of our present research was to develop a simple, economical and versatile approach to manufacture Franz type cells using additive manufacturing (AM).
- Methods : Graphical Franz diffusion cell designs were reproduced with a stereolithography (SLA) 3D printer and assessed over a minimum period of 24 h. The surface morphology of AM printouts was analysed before and after compatibility studies using scanning electron microscopy (SEM). Comparative permeation studies in both glass and AM Franz type diffusion cells were conducted using a caffeine solution (1.5 mg mL‑1), applied to a model silicone membrane.
- Results : Testing of the 3D printed scaffolds confirmed similar recovery of the permeant when compared to glass cells : 1.49 ± 0.01 and 1.50 ± 0.01 mg mL-1, respectively, after 72 h. No significant differences were visible from the SEM micrographs demonstrating consistent, smooth and non-porous surfaces of the AM Franz cells’ core structure. Permeation studies using transparent 3D printed constructs resulted in 12.85 ± 0.53 µg cm2 caffeine recovery in the receptor solution after 180 min with comparable permeant recovery, 11.49 ± 1.04 µg cm2, for the glass homologues.
- Conclusion : AM constructs can be considered as viable alternatives to the use of conventional glass apparatus offering a simple, reproducible and cost-effective method of replicating specialised laboratory glassware. A wider range of permeants will be investigated in future studies with these novel 3D printed Franz diffusion cells. |
| Note de contenu : |
- Fig. 1 : AM Franz diffusion type cell design generated in TinkerCADâ„¢ and cell printout top view
- Fig. 2 : Sputter coated AM Franz type diffusion cell attached onto adhesive carbon disk before SEM imaging with x and y axis cut edges
- Fig. 3 : Amount in mg mL-1 of CAF recovery from glass and 3D-printed receptor compartments at 0, 24, 48 and 72 h (n = 4, mean ± SD)
- Fig. 4 : SEM micrographs of AM Franz type diffusion cell from pre-compatibility study
- Fig. 5 : Amount of CAF permeation from initial dose per cm2 of PDMS membrane at 0, 15, 30, 45, 60, 90, 120 and 180 min using glass and 3D-printed Franz type diffusion cells (n = 4, mean ± SD)
- Table 1 : Physicochemical properties of caffeine (CAF) |
| DOI : |
https://doi.org/10.1111/ics.12618 |
| En ligne : |
https://drive.google.com/file/d/1G4mhxCFDUQpMS9OngbSGQVSQxKM4PR4q/view?usp=shari [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35293 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 42, N° 4 (08/2020) . - p. 415-419
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