[article]
| Titre : |
Attenuation of negative effects of senescence in human skin using an extract from Sphingomonas hydrophobicum: development of new skin care solution |
| Type de document : |
texte imprimé |
| Auteurs : |
S. Gervason, Auteur ; M. Napoli, Auteur ; A. Dreux-Zhiga, Auteur ; C. Lazzarelli, Auteur ; S. Garcier, Auteur ; A. Briand, Auteur ; M. Albouy, Auteur ; A. Thepot, Auteur ; Jean-Yves Berthon, Auteur ; Edith Filaire, Auteur |
| Année de publication : |
2019 |
| Article en page(s) : |
p. 391-397 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Estime de soi
PsychobiologieLa psychobiologie étudie le comportement humain dans une perspective biologique. Elle s'intéresse aux processus biologiques dans le corps et en particulier dans le cerveau, et leur rapport avec les comportements et pensées. La biopsychologie a pris une importance majeure durant le XXe siècle avec le développement important de la médecine scientifique, de la génétique, des neurosciences, et des méthodes d'imagerie cérébrale.
SphingomonasSphingomonas est un genre de protéobactéries de la famille des Sphingomonadaceae.
Vieillissement
Vieillissement cutané
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : Intrinsic skin ageing is mainly caused by cellular senescence. p16 and p21 are two important tumour suppressor proteins that play essential roles during cell proliferation and ageing through regulating the expression of several genes. Moreover, physical changes between the ages of 55 and 60 years affect one's physical and disrupt self-esteem. The cosmetics industry has focused on bioactive substances derived from natural products such as plants, mushrooms and marine algae to counteract the deleterious effect on skin senescence. Besides these products, compounds produced by bacteria may decelerate individual senescence.
- Methods : In order to evaluate the potential benefits of bacteria extract over skin ageing, we investigated whether a Sphingomonas hydrophobicum (SH) extract is able to protect our skin against senescence mechanisms. We used an ageing full-thickness skin equivalent model, which was treated or not with the bacteria extract in a systemic way for 42 days. p21 and p16 and senescence-associated galactosidase activity were used to detect cellular senescence with immunohistology. Using a psychobiological approach, we evaluated in vivo the effect of SH extract on self-esteem, isotropy and suppleness.
- Results : Sphingomonas extract significantly suppressed senescence associated with β-galactosidase activation. It also significantly inhibited the expression of cell cycle inhibitors (p. 21 and p. 16). At the same time, the bacteria extract has a significant positive impact on the issue by increasing the expression of versican and fibrillin-1. Significant improvements of self-esteem were reported after 56 days of SH extract application. These psychological benefits were accompanied by a significant improvement in skin suppleness and isotropy.
- Conclusion : Sphingomonas extract delays intrinsic skin ageing process by inhibiting cellular senescence, and has also the capability to restructure the skin. These beneficial physiological effects induced by SH extract have a positive influence on self-esteem. Because skin ageing causes emotional distress, SH extract can serve as an anti-ageing cosmeceutical agent and help to build a better psychological health, and help individuals to assume ageing. |
| Note de contenu : |
- MATERIALS AND METHODS : Bacterial strains and culture conditions - MTT cell viability assay - Reconstructed skin model - Immunohistological analysis - In vivo study - Isotropy - Biomechanical properties of the skin - Psychological parameter - Statistics
- RESULTS : Sphingomonas decreases the expression of senescence-related proteins - Sphingomonomas decreases the expression of β-galactosidase in the dermis - Expression of fibrillin-1 and versican - In vivo results |
| DOI : |
10.1111/ics.12534 |
| En ligne : |
https://drive.google.com/file/d/1LNFVIERfOir-tS_SKwP59SulkHM-9vlx/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33119 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 41, N° 4 (08/2019) . - p. 391-397
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Attenuation of negative effects of senescence in human skin using an extract from Sphingomonas hydrophobicum: development of new skin care solution in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 41, N° 4 (08/2019)
