[article]
| Titre : |
The contribution of neurogenic inflammation to sensitive skin : concepts, mechanisms and cosmeceutical intervention |
| Type de document : |
texte imprimé |
| Auteurs : |
Antonio Ferrer-Montiel, Auteur ; M. Camprubi-Robles, Auteur ; Nuria Garcia-Sanz, Auteur ; Ana Sempere, Auteur ; Pierluigi Valente, Auteur ; Wim Van Den Nest, Auteur ; Cristina Carreno, Auteur |
| Année de publication : |
2009 |
| Article en page(s) : |
p. 311-315 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Tags : |
Algogens Epidermis Immune system Nociceptor Sentitization |
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Cutaneous neurogenic inflammation is emerging as an underlying mechanism for several skin conditions. The intimate cross-talk between the cutaneous immune system and the periperal nervous system is fundamental for skin biology. However, an imbalance or dysfunction results in the onset of an inflammatory state that is reinforced by the synergic and complementary action of both systems. Cumulative evidence indicates that the termoreceptor TRPV1 is a key player of neurogenic inflammation. This receptor is activated by both physical and chemical stimuli, and its activity is potentiated by pro-inflammatory mediators. An increase in TRPV1 activity results in an increment of neuronal excitability that leads to the release of proalgesic agents that stimulate the immune system. Therefore, the TRPV1 receptor is being considered as a cosmeceutical target, and agents that reduce its activity will be useful cosmeceuticals. |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=3258 |
in IFSCC MAGAZINE > Vol. 11, N° 4 (10-11-12/2008) . - p. 311-315
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The contribution of neurogenic inflammation to sensitive skin : concepts, mechanisms and cosmeceutical intervention in IFSCC MAGAZINE, Vol. 11, N° 4 (10-11-12/2008)
