| Titre : |
Expression lines targeted via both synaptic pathways |
| Type de document : |
texte imprimé |
| Auteurs : |
Miriam Mateu, Auteur ; Ariadna Grau-Campistany, Auteur ; Silvia Pastor, Auteur ; Patricia Carulla, Auteur ; Julia A. Boras, Auteur ; Mikel Gorostiaga, Auteur |
| Année de publication : |
2019 |
| Article en page(s) : |
p. 137-140 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge:Antirides
Cosmétiques
Peau -- Soins et hygiène
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Munapsys demonstrated action on both pre- and post-synaptic pathways. It competed against Munc18-1 for its binding with syntaxin which is essentiel for the SNARE formation and it reduced the levels of ACh release by the pre-synaptic vesicles in the neuron. It also acted on AChR clustering, muscle membrane depolarization, calcium mobilisation and actomyosin cross-bridge and sliding. Finally, its efficacy as a wrinkle smoother was evaluated against a combination of benchmarks (covering both pathways) and proved to be similar or better at a lower concentration. In addition, Munapsys also presented good results in the lifting of sad smiles.
We conclude that Munapsys could be considered a real upgrade in the botulinum toxin-like ingredients field. |
| Note de contenu : |
- Munc18-1/Syntaxin-1 binding assay
- Pre-synaptic neurotransmitter release
- Post-synaptic gene expression modulation
- Calcium mobilisation in the sarcoplasm
- Myosin quantification
- Human neuron-muscle contraction
- Double-blind assessment of anti-wrinkles efficacy
- Lifting sad smiles
- Fig. 1 : Munapsys modulates both pre- and post-synaptic pathways
- Fig. 2 : Myosin decrease in human mature skeletal myocytes treated with Munapsys
- Fig. 3 : Frequency of contraction in a co-culture ofhuman motor neurons and human muscle cells compared with a benchmark
- Fig. 4 : Roughness improvement in a panel of volunteers that tested 3% Munapsys and a placebo
- Fig. 5 : Crow's feet images with PRIMOS of a volunteer of 37 years old that experienced a reduction in maximum wrinkle depth of 36.9 % after applying 3% Munapsys before and after 14 days. Volunteer of the panel that applied the 3% Munapsys and placebo
- Fig. 6 : Higher or similar efficacy wrinkle improvement with 3% Munapsys than with 5% benchmark
- Fig. 7 : Crow's feet image with PRI MOS of a volunteer of 45 years old with an improvement in wrinkle volume of 32.0% after applying 3% Munapsys before and after 7 days. Volunteer of the panel that applied 3% Munapsys and 5% benchmarks
- Fig. 8 : Images of a volunteer of 51 years old that improved the dropping of the commissures by 16.7% after applying a cream with 3% Munapsys before and after 28 days |
| En ligne : |
https://drive.google.com/file/d/14vCSwwa3XdZzAeeQFo8t65YxWAeSbzzB/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=32257 |
in PERSONAL CARE EUROPE > Vol. 13, N° 3 (04/2019) . - p. 137-140
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Expression lines targeted via both synaptic pathways in PERSONAL CARE EUROPE, Vol. 13, N° 3 (04/2019)
