| Titre : |
Stem cell activation for a V-shaped face |
| Type de document : |
texte imprimé |
| Auteurs : |
Franziska Wandrey, Auteur ; Daniel Schmid, Auteur ; Fred Zülli, Auteur |
| Année de publication : |
2019 |
| Article en page(s) : |
p. 35-38 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge
Antiâge:Antirides
Dermo-cosmétologie
Extraits de plantes:Extraits (pharmacie)
Peau -- Soins et hygiène
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
As we age, the production of collagen and elastin is reduced, which results in sagging skin that can most notably be observed at the face contours of the jawline. Mesenchymal stem cells have been shown to improve collagen productionsand regenerate the skin, for example during wound healing. These processes are mediated by vesicles known as exosomes which are produced and secreted by these stem cells. A novel active ingredient based on goji plant stem cells was shown to improve the stemness of aged mesenchymal stem cells as well as increase exosome signalling by mesenchymal stem cells, which in turn improves extracellular matrix production in fibroblasts. The improved extracellular matrix rejuvenates the skin by improving skin density, reducing wrinkles and reshaping the face for an improved V-shape of the face |
| Note de contenu : |
- Cell-to-cell communication via exosomes
- Goji - the superfruit
- Producing plant stem celle
- MATERIALS AND METHODS : Expression of stem cell markers in age MSCs - Quantification of exosome production by MSCs - Gene expression in fibroblasts after treatment with MSC-conditioned medium - Clinical study on photoaged skin - Skin study on oval face shape
- RESULTS AND DISCUSSION : Maintenance of stemness in aged MSCs - Increase in MSC exosome production - Stimulation of extracellular matrix genes through cell-to-cell communication - Improvement of wrinkle depth and skin density in photoaged skin - Improvement of the oval face shape
- Fig. 1 : Schematic illustration of exosome signalling between mesenchyma stem cells and fibroblasts
- Fig. 2 : Increase in stem cell marker expression in aged mesenchymal stem cells after treatment with goji stem cell extract
- Fig. 3 : Increase in exosome production by mesenchymal stem cells after treatment with goji stem cell extract
- Fig. 4 : Gene expression of extracellular matrix genes by fibroblasts treated by conditioned medium for either untreated or goji stem cell extract treated mesenchymal stem cells
- Fig. 5 : Increase in epidermis + dermis density after 28 days treatment with 0.4 % goji stem cell active
- Fig. 6 : Representative ultrasound image of the increase in epidermis + dermis density after 28 days treatment with 0.4 % goji stem cell active. SLEB = subepidermal low-echogenic band
- Fig. 7 : Decrease in wrinkle depth on crow's feet after 56 days treatment with 0.4 % goji stem cell active
- Fig. 8 : Representative before/after pictures of two volunteers to illustrate the decrease in wrinkle depth on crow's feet after 56 days treatment with 0.4 % goji stem cell active
- Fig. 9 : Improvement of oval face shape after 28 days treatment with 0.4 % goji stem cell active
- Fig. 10 : Visibly improved V-shape of the face after 28 days treatment with 0.4 % goji stem cell active |
| En ligne : |
https://drive.google.com/file/d/1w9R1CQkBtghzvjHrou4HlI_jaPJoXpPY/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=32231 |
in PERSONAL CARE EUROPE > Vol. 13, N° 3 (04/2019) . - p. 35-38
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Stem cell activation for a V-shaped face in PERSONAL CARE EUROPE, Vol. 13, N° 3 (04/2019)
