[article]
| Titre : |
New data on topical peptide for needle-free facial remodeling |
| Type de document : |
texte imprimé |
| Auteurs : |
Mathias Gempeler, Auteur ; Sonia Dawson, Auteur ; Remo Campiche |
| Année de publication : |
2018 |
| Article en page(s) : |
p. 16-20 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge
Composés organiques -- Synthèse
Cosmétiques
Hyaluronique, acideL'acide hyaluronique est un type de polysaccharide (plus précisément une glycosaminoglycane) non fixé à une protéine centrale et largement réparti parmi les tissus conjonctifs, épithéliaux et nerveux animaux.
Il se trouve notamment dans l'humeur vitrée et le liquide synovial. Il est l'un des principaux composants de la matrice extracellulaire ainsi que de certaines mucoprotéines lorsqu'il est associé à une fraction protéique.
Depuis les années 1990, il est très utilisé dans divers dispositifs médicaux, médicamenteux et cosmétiques (présenté dans ce dernier cas comme "antistatique, humectant, hydratant, conditionneur cutané, anti-âge, etc."), bénéficiant d'un effet de mode grandement soutenu par une large publicité commerciale.
Contribuant de façon significative à la prolifération et à la migration des cellules, l'acide hyaluronique est aussi impliqué dans la progression de certains cancers. (Wikipedia)
Peau -- Soins et hygiène
Peptides
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Hyaluronic acid (HA) or hyaluronan is a compound found in skin which is crucial to the smooth and full appearance of the face. It is frequently used as a filler injection in the cosmetic surgery industry. Since 2006, DSM Nutritional Products Ltd. (DSM) has known that its proprietary peptide molecule SYN®HYCAN (INCI: Tetradecyl aminobutyroylvalylaminobutyric Urea Trifluoroacetate) was effective in significantly upregulating hyaluronic acid expression within the skin itself. The aim of the research presented here was to make its demonstrated efficacy tangible and visible with novel technologies.
The data shows just how much this peptide boosts HA synthesis in dermal and epidermal cells in vitro and ex vivo. Moreover, thanks to cutting-edge 3D visualization technology and a novel, non-contact compression device, we can see how this compound significantly improves skin volume and restores firmness across multiple facial areas in vivo. Human ileedback has also delivered useful results. Over 87 % of panelists reported that their skin felt supple and smooth and nearly 70 % confirmed that their skin had more elasticity.
DSM's peptide solution can therefore be used as an effective cosmetic alternative to dermal fillers or to enhance the effects of HA injections in between treatments. |
| Note de contenu : |
- The rise and rise of hyaluronic acid
- Boosting HA with peptides
- In vitro studies
- New ex vivo study
- New in vivo studies
- An injection-free way to firmer facial skin
- Fig. 1 : Different facial zones that can be augmented by dermal fillers
- Fig. 2 : Mimicking TGFβ1 activation for increased HA synthesis
- Fig. 3 : HA synthesis in keratinocyte (Test A) and fibroblast (Test B) cell culture
- Fig. 4 : Tect C - increase in biosynthesis (%) after treatment with DSM's peptide, regular TGFβ1, and a control
- Fig. 5 : Visible increase in hyaluronic acid ex vivo (blue staining). UVR = UV radiation
- Fig. 6 : Semi-quantitative analysis using image J software. *p<0.05 vs vehicle by paired student's t-test
- Fig. 7a 3D imaging showing skin volume change over time (base formulation without SYN-HYCAN)
- Fig. 7b 3D imaging showing skin volume change over time (base formulation with 2.5% SYN-HYCAN
- Fig. 8 : Skin firmness at day 0 and day 29 after treatment with DSM's peptide at 2.5%, the base formulation only, and a 3% competitor formulation. Shown is the depth of the skin's deformation evoked by the DynaSKIN device. After 29 days of treatment with a 2.5% SYN-HYCAN formulation we found a significantly smaller deofmration indicative for firmer skin |
| En ligne : |
https://drive.google.com/file/d/1gTdDjl3_8-5czFfOxns4gEm0ye_siVYB/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=30954 |
in SOFW JOURNAL > Vol. 144, N° 9 (09/2018) . - p. 16-20
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New data on topical peptide for needle-free facial remodeling in SOFW JOURNAL, Vol. 144, N° 9 (09/2018)
