| Titre : |
Harnessing discoveries in epigenetics to help revitalize fibroblasts : BASF's new anti-aging actives target epigenetic mechanisms |
| Type de document : |
texte imprimé |
| Auteurs : |
Sabine Pain, Auteur ; Florence Trombini, Auteur ; Valérie André-Frei ; Corinne Reymermier |
| Année de publication : |
2018 |
| Article en page(s) : |
p. 10-15 |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge
Biomolécules actives
Cosmétiques
Densité cutanée
EpigénétiqueL'épigénétique (mot-valise de "épigenèse" et "génétique") est la discipline de la biologie qui étudie la nature des mécanismes modifiant de manière réversible, transmissible (lors des divisions cellulaires) et adaptative l'expression des gènes sans en changer la séquence nucléotidique (ADN)
"Alors que la génétique correspond à l'étude des gènes, l'épigénétique s’intéresse à une "couche" d’informations complémentaires qui définit comment ces gènes vont être utilisés par une cellule ou… ne pas l'être".
"C'est un concept qui dément en partie la "fatalité" des gènes".
Extraits de plantes:Extraits (pharmacie)
Fibroblastes
Peau -- Soins et hygiène
Protéines
Régénération (biologie)
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
To explore the field of epigenetics in greater detail, BASF researchers have joined forces and established an interdisciplinary innovation platform. Together with experts from public and private research institutions, they are exploring how modulations to our gene expression, caused by either chronological aging or environmental factors, can be mapped and controlled. New anti-aging active ingredients harness the platform's findings. Dermagenist®, an extract of Origanum majorana leaves, is the first active ingredient that re-activates fibroblasts by protecting them from epigenetic modifications and stimulating their vitality through LOXL1 promoter re-activation. A clinical study demonstrated an 18 % improvement in skin density after tvvo months of application, and a 15% improvement in skin firmness after three months. RNAge®, an extract of Hippophae rhamnoides seeds, fights chronological microRNA Let-7b dysregulation. Researchers has demonstrated that Let-7b is involved in epigenetic regulation and the balancing of proteins in both the extracellular matrix and the proteoglycan network required for a well-balanced dermal structure. RNAge inhibited Let-7b expression by 39 % versus the untreated control. The skin rebuilds from deep within, recovering its density (+26%) and firmness (+18.5%) for a healthy and youthful appearance. |
| Note de contenu : |
- REAWAKENING FIBROBLASTS' POTENTIAL
- PROOF OF CONCEPT : IN VITRO ASSESSMENTS : Effect of dermagenist on LOXL1 mRNA expression - Effect of dermagenist on pro-collagen 1 and BMP-1 - Effect of dermagenist on actin organization
- PROOF OF CONCEPT : IN VIVO ASSESSMENTS : Effect of dermagenist on dermal density and skin firmness - Helping fibroblasts renew vital proteins - Epigenetic protein equalizer miRNA let-7b
- PROOF OF CONCEPT : IN VITRO ASSESSMENTS : Effect of RNAge on miRNA let-7b expression - Effect of RNAge on structural properties of the dermis
- PROOF OF CONCEPT : IN VIVO ASSESSMENTS : Effect of RNAge on dermal density, skin firmness and half-chin angle
Table : Five proteins modulated by miRNA let-7b |
| En ligne : |
https://drive.google.com/file/d/1r3HsNZWeeQ_owSp3f4-gKWUyaxQs2YZk/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=30952 |
in SOFW JOURNAL > Vol. 144, N° 9 (09/2018) . - p. 10-15
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Harnessing discoveries in epigenetics to help revitalize fibroblasts in SOFW JOURNAL, Vol. 144, N° 9 (09/2018)
