Titre : |
PVP-wrapped fullerenes as skin protection |
Type de document : |
texte imprimé |
Auteurs : |
Mio Murakami, Auteur |
Année de publication : |
2018 |
Article en page(s) : |
p. 117-120 |
Note générale : |
Bibliogr. |
Langues : |
Anglais (eng) |
Catégories : |
Antioxydants Cosmétiques Fullerènes Peau -- Soins et hygiène Perte insensible en eau Polyvinylpyrrolidone
|
Index. décimale : |
668.5 Parfums et cosmétiques |
Résumé : |
Rough skin, which occurs because of barrier disruption, is one of the most important cosmetic problems. The outermost surface of the body is covered by the stratum corneum, which is an effective barrier essential for preventing epidermal water loss and impeding the entry of external stimulus. The stratum corneum comprises layered cornified cells produced by the terminal differentiation of keratinocytes and intercellular lipids. Whether Radical Sponge has a barrier recovery effect was investigated. Radical Sponge prevented the decrease in cornified envelope and transglutaminase-1 mRNA expression induced by ultraviolet radiation. In addition, it could lessen oxidative stress-induced water loss. In human studies, Radical Sponge was shown to accelerate the recovery of barrier disruption by tape-stripping, and the combination of Radical Sponge and hyaluronic acid further accelerated the recovery. These results suggest that Radical Sponge as an antioxidant may offer a new solution for rough skin. |
Note de contenu : |
- What is fullerene ?
- Measurement of the cornified envelope
- Determination of transglutaminase-1 m-RNA expression
- Measurement of transepidermal water loss (TEWL) in a 3D skin model
- Human study
- FIGURES : 1. Rough skin and causes - 2. Effects of the radical sponge (RS), PVP on ratios of cells with cornified envelope (CE). The bars represent means with SDs of three experiment. *P<0.05, **P<0.01 - 3. Effects of the Radical Sponge (RS) on RT-PCR of transglutaminase-1. The bars represent means with SDs of three experiments. **P<0.01 versus non-UV control at ΔCT stage - 4. Effect of oxidative stress (tert-butyl peroxide ; t-BuOOH) on trans-epidermal water loss (TEWL). The bars represent means SDs of three to four experiments. *P<0.05 - 5. Clinical evaluation of barrier recovery of the Radical Sponge (RS). The points represent means with SDs of 10 subjects. *P<0.05 - 6. Clinical evaluation of the combined effect of the Radical Sponge (RS) and hyaluronic acid (HA). The bars represent means with SDs of nine subjects. *P<0.05, **P<0.01 - 7. Barrier recovery effect of the Radical Sponge |
En ligne : |
https://drive.google.com/file/d/1ssWx5kRQZVAub4wTHVd0dgxIXBfPR_e9/view?usp=drive [...] |
Format de la ressource électronique : |
Pdf |
Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=30460 |
in PERSONAL CARE EUROPE > Vol. 12, N° 2 (04/2018) . - p. 117-120