| Titre : |
SPF assessment revisited - status and outlook |
| Type de document : |
texte imprimé |
| Auteurs : |
Uli Osterwalder, Auteur ; Rolf Schütz, Auteur ; Jürgen Vollhardt, Auteur |
| Année de publication : |
2018 |
| Article en page(s) : |
p. 38-44 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Evaluation
Facteur de protection solaire
Peau -- Soins et hygiène
Produits antisolaires
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
We present the latest alternatives to the in vivo SPF gold standard and discuss their potential and procedures for their validation. The relevance of erythema as SPF endpoint is undisputed, especially as erythema and at least non-melanoma-skin-cancer share a similar action spectrum. Skin and sunscreens interact in a complex fashion, producing an absorption phenomenon far removed from the laboratory cuvette. This continues to represent a significant trueness challenge for any replacement method. We have choices for an alternative method, from in silico and in vitro which require no human testing to a hybrid that involves humans but with negligible irradiation burden. Performing method validation is a key step in the process and requires a solid data foundation to select a suitable method that assures future success. |
| Note de contenu : |
- The relevance of SPF for skin cancer prevention
- SPF test ISO 24444 - the gold standard, in vivo
- Alternative SPF methods
- Single exposure SPF test, in vivo
- Hybrid diffuse reflectance spectroscopy method (H-DRS) in vivo/in vitro
- Transmission SPF, in vitro
- Calculated SPF, in silico
- Oveview of potential of SPF assessment methods
- validation procedure for alternative SPF methods
- The way forward
- FIGURES : 1. "It is better to be roughly right than precisely wrong." - John Maynard Keynes. One should not be misled by high precision The scatter of the "roughly right" case can always be reduced by more data that will make it possible to narrow the distance from the true value - at some extra cost, of course
- 2. Very high correlation found between erythema and skin cancer action spectra - 3. SPF gold standard and alternatives. Classification of assessment method according totype - 4. Distribution of individual sun protection factors (SPFi) for SPF-true = 36, standard deviation = 4.4. Blue line : SPF label = 30. Area left of blue line : proportion of erythema in the population (8.6 %) - 5. Experimental setup of H-DRS measurement (in vivo DRS and in vitro ISO 24443) - 6. Principle of in silico method based on UV filter concentration - 7. Overview of methods and their role in supporting/replacing the current ISO 24444
- Table : Status of gold standard ISO 24444 and potential alternatives |
| En ligne : |
https://drive.google.com/file/d/1Zv7FuuwQxo3baBljIlrMNpi3zkzQlLVo/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=30424 |
in SOFW JOURNAL > Vol. 144, N° 4 (04/2018) . - p. 38-44
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SPF assessment revisited - status and outlook in SOFW JOURNAL, Vol. 144, N° 4 (04/2018)
