Skin care vaccine induces self-maintenance system / Chaejin Lim in PERSONAL CARE EUROPE, Vol. 8, N° 3 (04/2015)  

[article]  inPERSONAL CARE EUROPE > Vol. 8, N° 3 (04/2015) . - p. 90-94 Titre : Skin care vaccine induces self-maintenance system Type de document : texte imprimé Auteurs : Chaejin Lim, Auteur ; Keedon Park, Auteur ; Hiroyuki Nomura, Auteur ; Atsushi Takeoka, Auteur Année de publication : 2015 Article en page(s) : p. 90-94 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antioxydants Autophagie L’autophagie, autolyse ou autophagocytose, désigne une dégradation d'une partie du cytoplasme de la cellule par ses propres lysosomes. L'histolyse est le même processus, mais intervenant lors d'une métamorphose, il est utile à l'organisme (par exemple, les amphibiens). L'histolyse est également présente au cours du développement embryonnaire ou en fin de lactation. Le terme d'autophagie regroupe plusieurs voies de dégradation lysosomale des constituants cellulaires, essentielles à l’homéostasie cellulaire. Il existe trois types différents d’autophagies dont : la microautophagie, l’autophagie réalisée par des protéines chaperonnes, et la macroautophagie (la forme principale). La macroautophagie, appelée couramment autophagie, est un mécanisme permettant à la cellule de digérer une partie de son contenu, que ce soit du cytoplasme, des protéines ou des organites cellulaires. C’est la seule voie qui puisse dégrader massivement des macromolécules et des organites, c’est une voie de dégradation alternative à celle du protéasome. Chimie biomimétique Cosmétiques Facteur naturel d'hydratation Peau -- Soins et hygiène Peptides Produits hydratants Index. décimale : 668.5 Parfums et cosmétiques Résumé : Skin care is the major topic for the personal care market. People demand to remain young, with better looks as they age, such as smaller pores, fewer wrinkles, and less sagging, and to moderate skin disorders, such as irritation, dryness, redness, dandruff etc. The former target is mainly known as anti-ageing. The main target is to remodel and rescue our skin from intrinsic and extrinsic damage. People want to keep their youth or even to turn back time in order to look younger. This market is strongy growing. So, numerous anti-ageing ingredients have been developed to focus on the reactivation or boosting of cutaneous tells' proliferation and/or skin component secretion, such as extracellular matrix-like collagen, hyaluronic acid. But on the other hand, the latter focuses are less limited to skin normalisation and/or moderation from disorder. For those targets, the focus is on skin homeostasis to naturally keep its correct levels. This skin mechanism works in normal skin but weakens due to intrinsic bio-stress, chronological ageing or immunity imbalances, and/or extrinsic stress, chemicals and sunlight (UVs/IRs). In this study, we examined the effects of an innovative biomimetic peptide, which was developed from naturel moisturising factor (NMF), for regulating biological mechanisms involved in skin homeostasis, by measuring a cellular detoxification response to extrinsic oxidative stress and an efficacy on cellular maintenance system of redox, chaperone and autophagy. At the same time, we performed a preliminary clinical trial for hydration effcacy of this moisture peptide, to assess the physical effect of the peptide, not only biological efficacy. Our results pointed out this new NMF derived biomimetic peptide can show not only physical moisturising efficacy like the original skin, NMF, rather than well-known the moisturising compound hyaluronic acid, also bas biological efficacy to induce a self-maintenance property compared to the well-known antioxidant, ascorbic acid. These efficacies are confirmed by cDNA microarray, qPCR and protein expression. Interestingly, we found this peptide could promote autophagy in a similar way to potential anti-ageing medicine, rapamycin. In conclusion, this study provides potential efficacies of this NMF-derived moisture peptide as a 'skin care vaccine' which induces the self-protection mechanism to maintain the healthy condition of skin, and moreover we can expect anti-ageing efficacy though cutaneous stem tell maintenance by autophagy. Note de contenu : - METHODS : Clinical moisturising test - Intracellular ROS scavenging activity - cDNA microarray - Western blot analysis - Puncta formation assay - RESULTS : Moisturising : the confirmation of physical efficacy of NMF derived moisture peptide - Detoxification : potential efficacy of intracellular antioxidation of moisture peptide - Cutaneous maintenance : autophagy En ligne : https://drive.google.com/file/d/1heMSr650XJjN742XcVf13Juh9pcLRUig/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=23705 [article]

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Code-barres	Cote	Support	Localisation	Section	Disponibilité
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