[article]
| Titre : |
Skin ageing detox system reacts to cellular senescence |
| Type de document : |
texte imprimé |
| Auteurs : |
Alain Thibodeau, Auteur |
| Année de publication : |
2017 |
| Article en page(s) : |
p. 99-102 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge
Extraits de plantes:Extraits (pharmacie)
Goyavier et constituants
Peau -- Soins et hygiène
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Skin cells are constantly exposed to environmental stresses that will inexorably cause structural and biological damage. Oxidative reactions, DNA damage, metabolic dysregulations or even tell death are direct consequences of such environmental insults. Indirect effects, through the production of enzymes, cytokines and interleukines, may aiso occur and will eventually translate into the degradation of macromolecules, chronic inflammatory reactions, chemoattraction and immunosuppression. Depending upon the extent of damage they undergo, skin cells can take various decisional pathways. If the extent of damage is relatively low, cells will trigger a repair process to fix any deteriorated molecuies or impaired metabolic pathways before resuming their normal functions. If excessive damage is caused making it impossible (or too energy-consuming) to repair, cells will undergo organised tell death also called apoptosis. In that scenario cells will be eiiminated. When the extent of damage is 'medium' — significant enough ta overwhelm the repair machinery but not sufficient to command apoptosis — Cells will become senescent. Upon entering senescence, cells wili no longer divide into daughter cells. Senescence is thus a mechanism of protection or an adaptation to stress preventing cells from transmitting damage (genetic) to their progeny. However, unlike apoptotic cells, senescent cells remain a live, metabolically active and they accumulate in the skin as we age. The accumulation of senescent cells can cause a form of age-dependent endogeneous toxification of the skin. A likely link between cellular senescence and ageing and age-related conditions is acknowledged by the scientific community. |
| Note de contenu : |
- Cellular senescence contributes to the ageing process
- Consequences of senescence - Actions of NF-kB-regulated SASP pathways
- Preventing activation and nuclear translocationof NF-kB
- Locking NF-kB into an inactive configuration - Action of the guava leaf active on selective SASP factors
- FIGURES : 1. Activation of NF-KB and SASP pathways upon cellular senescence induction - 2. A. Skin reactions to the secretion of eotaxin by senescent epidermal cells - B. Skin reaction to the activation of COX-2 and the secretion of PGE2 by senescent epidermal cells - C. Skin reactions to the activation of iNOS and the secretion of NO by senescent epidermals cells - 3. Activation andnuclear translocation of NF-kB in a TNF-?-induced senescence model - Inhibition by the Bioptimize Guava leaf active - 4. Inhibition of lkB degradation by the Bioptimized Guava leaf active - 5. Effects of the guava leaf active on the production of selective SASP factors - 6. Summary of the guava leaf active actions in a cellular senescence model |
| En ligne : |
https://drive.google.com/file/d/1It16Scr3w3KDkbCHeqoj7PdwNwyDy2O9/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=28345 |
in PERSONAL CARE EUROPE > Vol. 11, N° 2 (04/2017) . - p. 99-102
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Skin ageing detox system reacts to cellular senescence in PERSONAL CARE EUROPE, Vol. 11, N° 2 (04/2017)
