[article]
| Titre : |
Next generation skin sensitisation testing |
| Type de document : |
texte imprimé |
| Auteurs : |
Anki Malmborg Hager, Auteur ; Henrik Johansson, Auteur ; Malin Lindstedt, Auteur ; Carl A. K. Borrebaeck, Auteur |
| Année de publication : |
2016 |
| Article en page(s) : |
p. 55-58 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Génétique
Tests cutanés
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
DNA is the software that predicts human phenotypes. Genomics utilises DNA as such a piece of software, which in several recent applications has been demonstrated to be able to predict a number of biological features, enabling anything from face recognition to vaccine development.' The tremendous information content, harboured in the DNA, should be harnessed in tests of cosmetic ingredients and formulations, to get a complete insight into what is happening in the body when these types of products are applied to the human skin. This type of complex information gives a holistic view of a human condition that many of us are familier with, such as e.g. allergic contact dermatitis, and has the potentiel not only to classify chemicals used in cosmetics but also to determine the magnitude to which a chemical affects the human body (the potency).
This distinguishes genomics from most other test principles, where in many cases only one or two markers are being monitored, such as DC activation markers (CD86, CD54), genes involved in cytoprotective responses to oxidative stress or electrophilic compounds (Nrf2, Keap1), or proinflammatory cytokines, (e.g. IL18).
Genomics utilises the entire transcriptonne of tells, tissues or organs that have been exposed to a particular chemical in order to provide insight also into what mechanisms are activated in each specific tell, tissue or organ. The transcriptome, i.e. the expressed levels of genes, are subsequently analysed to deliver the appropriate information, in this case whether or nota certain chemical compound is an allergen. There are a number of applicable genomic technologies, including whole genome microarray technology. The measured endpoints for such a microarray are the transcribed mRNA levels of over 20,000 genes, consequently harbouring massive amounts of information, which can be deciphered in silico into knowledge by bioinforrnatics, focusing on yes/no decision values, potency, pathways, or complex mechanistic analyses. This clearly distinguish genomic test principles from all other more traditional approaches and consequently holds tremendous promise for advanced testing of cosmetic ingredients. |
| Note de contenu : |
- Animal ban
- Genomics explained
- Alternative methods
- A new multiparametric genomic test
- Principles of the protocol |
| En ligne : |
https://drive.google.com/file/d/1TKLxgq0CvjStsSaBU_Y0FJekmjGmSkoR/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=27247 |
in PERSONAL CARE EUROPE > Vol. 9, N° 4 (09/2016) . - p. 55-58
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Next generation skin sensitisation testing in PERSONAL CARE EUROPE, Vol. 9, N° 4 (09/2016)
