| Titre : |
Face and body cellular senescence delayer : BASF's anti-ageint active Lys'lastine V reduces progerin and increases klotho, while re-inducing expression of LOXL |
| Type de document : |
texte imprimé |
| Auteurs : |
Sabrina Leoty-Okombi, Auteur ; Catherine Bonnaud-Rosaye, Auteur ; Valérie André-Frei, Auteur ; David Bothorel, Auteur |
| Année de publication : |
2016 |
| Article en page(s) : |
p. 2-6 |
| Langues : |
Anglais (eng) |
| Catégories : |
Biomolécules actives
Cosmétiques
Fibroblastes
Peau -- Soins et hygiène
Progérine
Vieillissement
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
With Lys'IastineTM V, we present an anti-ageing active that targets the cellular senescence of fibroblasts. In vitro, 0.025% Lys'lastine V significantly reduced the accumulation of progerin, the "ageing protein" that is linked to replicative senescence in fibroblasts (-54 %). Furthermore, 0.05 % Lys'lastine V significantly increased levels of the "youth protein" Klotho (+34%), while 1 % Lyslastine V re-induced expression of lysyl oxidase-like (LOXL) in reconstructed dermis (MimedermTM) (+64%) and increased levels of LOXL in a reconstructed skin model (MimeskinTm). LOXL is the cross-Iinking agent responsible for the deposit of tropoelastin on microfibrils and therefore the synthesis of functional elastic fibers in the dermis — but from the age of 18, it decreases rapidly. By re-inducing LOXL, this BASF active helps restore the skin's elasticity, ln a clinical study, Lys'lastine V was proven to significantly improve the skin's suppleness, both on the face and décolleté. |
| Note de contenu : |
- CELLULAR SENESCENCE DELAYER
- PROOF OF CONCEPT - IN VITRO ASSESSMENTS : Effect of Lys'lastine V on progerin - Effect of Lys'lastine V on Klotho - Effect of Lys'lastine V on LOXL
- PROOF OF CONCEPT - IN VIVO ASSESSMENTS : Effect of Lys'lastine V on the decolleté
- Dill (Anethum graveolens
- FIGURES : 1. Senescent fibroblasts and effects of Lys'lastine V - 2. Progerin expression in dermal fibroblasts after four days with Lys'lastine V starting at 0.01% vs. untreated control - 3. Klotho expression in dermal fibroblasts after 24 hours with Lys'lastine V starting at 0.01% vs. untreated control - 4. Quantitative RT PCR analysis of mRNA expression of tropoelastin and LOXL using Mimederm - 5. Skin stretchability (RO) and skin stretchability after three suctions (R3) with 1% Lys'lastine V vs. placebo |
| En ligne : |
https://drive.google.com/file/d/1argutiVAWGjz5TeNV-dlBOfSvLWy5QfV/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=27190 |
in SOFW JOURNAL > Vol. 142, N° 9 (09/2016) . - p. 2-6
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Face and body cellular senescence delayer in SOFW JOURNAL, Vol. 142, N° 9 (09/2016)
