| Titre : |
Agastache mexicana counteracts the effects of psychological stress on skin |
| Type de document : |
texte imprimé |
| Auteurs : |
Laura Gallego, Auteur ; Blanca Martinez-Teipel, Auteur ; Ricard Armengol, Auteur |
| Année de publication : |
2016 |
| Article en page(s) : |
p. 8-16 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Anti-inflammatoires
Biomolécules actives
Cosmétiques
Extraits de plantes:Extraits (pharmacie)
Peau -- Soins et hygiène
Stress -- Effets physiologiques
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Nowadays, psychological stress is a very relevant aspect in daily life. lt occurs as a result of a stimulus, which leads to the activation of several physiological systems among them the activation of the HPA axis. Once activated it causes the release of key stress molecules which leads further to a profound alteration of immune responses. The inflammatory reaction itself is managed by the nuclear factor (NF)-kappa B, which is able to translocate to the cell nucleus once psychological stress is detected. In the nucleus it binds to the DNA inside the cell to regulate the expression of numerous components of the immune system.
if stress becomes a chronic situation our organism reaches a phase of exhaustion with adverse consequences. Related to our skin, such consequences could be the outbreak or worsening of several disorders such as rosacea, psoriasis and other inflammatory events like acne.
Our laboratory has developed an active, derived from Agastache mexicana, capable of counteracting the consequences that psychological stress can unleash on the skin. It has been successfully demonstrated that this natural active is able to inhibit the translocation of NF-KB to the nucleus in Keratinocytes. lt has also been confirmed that the active inhibits the release of highly up-regulated cytokines. In vivo studies have shown a reduction of continued vasodilation by between 25 and 30 %. It also enables capillaries to recover their ability to contract and improve their strength and integrity, reducing skin redness. By using a thermal camera it was shown that this active reduces skin temperature by 0.4 degrees in subjects with stress and/or skin prone to develop rosacea. Chromameter measurements showed a reduction of skin redness by 9%. The active also confirmed a positive impact on the skin barrier as it reduced skin water loss by 13 % and an improvement of skin hydration by 6 %.
The natural active AgascalmTM derived from Agastache mexicana can be strongly recommended as an active ingredient with excellent anti-inflammatory activity that modulates the biochemical mechanisms that link psychological stress with skin deterioration. |
| Note de contenu : |
- INTRODUCTION : The brain-skin link - Consequences and signs of psychological stress in skin - Natural options to counteract psychological effects on skin
- MATERIALS AND METHODS : In vitro : NF-κB translocation - In situ immunolabeling - Transcriptional effects - RtqPCR array - Cytokines release - Cytometric bead array - Instrumental analysis - Evaluation of the skin microvascular tonicity - Evaluation of the anti-redness efficacy - Color analyzer - Imagine analysis - Evaluation of the skin barrier and moisturizing - Skin barrier by transepidermal water loss - Skin moisturizing by corneometry - Statistical data analysis
- RESULTS AND DISCUSSION : In vitro : NF-κB translocation - In situ immunolabeling - Transcriptional effect - RT-qPCR array - Cytokines release - Cytometric bead array - In vivo : Evaluation of the skin microvascular tonicity - Evaluation of the anti-redness efficacy - Evaluation of the skin barrier and moisturizing improvement |
| En ligne : |
https://drive.google.com/file/d/1BqB_D4yi6Sc3b4AYSfk8DYKRINGQcLqV/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=26315 |
in SOFW JOURNAL > Vol. 142, N° 5 (05/2016) . - p. 8-16
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Agastache mexicana counteracts the effects of psychological stress on skin in SOFW JOURNAL, Vol. 142, N° 5 (05/2016)
