Accueil
Détail de l'auteur
Auteur James R. Schwartz |
Documents disponibles écrits par cet auteur
Ajouter le résultat dans votre panier Affiner la recherche
Enhanced piroctone olamine retention from shampoo for superior anti-dandruff efficacy / Eric S. Johnson in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 2 (03-04/2023)
[article]
Titre : Enhanced piroctone olamine retention from shampoo for superior anti-dandruff efficacy Type de document : document électronique Auteurs : Eric S. Johnson, Auteur ; Debora W. Chang, Auteur ; James R. Schwartz, Auteur ; Ulrike Blume-Peytavi, Auteur ; James P. Henry, Auteur ; Tamara L. Caterino, Auteur ; Allison L. Talley, Auteur Année de publication : 2023 Article en page(s) : p. 236-245 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antifongiques
Antipelliculaires
Cheveux -- Soins et hygiène
Cosmétiques
Cuir chevelu
Dermatite sébhorrhéique
Desquamation
Etudes cliniques
Pellicules (dermatologie)
Piroctone olamine
Produits capillaires
shampooingsIndex. décimale : 668.5 Parfums et cosmétiques Résumé : - Background : Dandruff is a pervasive chronic condition which negatively impacts quality of life. Effective treatment requires efficient delivery of scalp benefit agents that control commensal scalp Malassezia levels. Delivery of benefit agents from shampoos requires balancing many technical parameters to achieve the desired outcome without sacrificing secondary parameters, such as cosmetic attributes.
- Objectives : To develop formulation technologies that increase the shampoo delivery efficiency of the scalp benefit agent piroctone olamine (PO). Increased delivery should result in increased anti-dandruff efficacy.
- Methods : Micellar Stability and Association parameters were quantified via dynamic surface tension and nuclear magnetic resonance (NMR) diffusion parameters, respectively. PO delivery has been assessed in vivo both on the scalp surface and follicular infindibula using extraction procedures and analytical analysis. Clinical anti-dandruff efficacy was assessed for an advanced delivery technology prototype in comparison to standard delivery technology.
- Results : Shampoo prototypes have been developed that increase the delivery efficiency of PO. Both surfactant and polymer coacervate-based approaches have been developed. Decreased micellar stability results in weaker association between PO and micelles, resulting in more efficient PO retention on the scalp surface and delivery to the infundibula. Increased charge density of cationic polymers optimizes coacervation enabling improved PO delivery as well. Increased PO delivery has been shown clinically to result in higher anti-dandruff efficacy as measured by both visible flakes and underlying biomarkers.
- Conclusion : Increased efficiency PO delivery shampoos have been developed by optimization of both surfactant and coacervate parameters. The increased deposition efficiency results in significantly more products with significantly greater anti-dandruff efficacy.Note de contenu : - MATERIALS AND METHODS : Shampoo products and compositions evaluated - Measurement of Micellar Stability parameter (θ) - Measurement of Micellar Association parameter (Ds/Da) - Measurement of scalp surface retention of piroctone olamine in vivo - Measurement of infundibular delivery of piroctone olamine in vivo - Clinical efficacy study design - Assessment of flaking severity - Assessment of histamine and ratio of IL1ra/IL-1α from scalp surface - Test products - Statistical analysis
- RESULTS : Micellar Stability parameter evaluations - Micellar Association parameter (Ds/Da) - Scalp surface retention of piroctone olamine in vivo - Infundibular delivery of piroctone olamine in vivo - Evaluation of Anti-Dandruff clinical efficacy
- Table 1 : Summary of shampoo compositions evaluated
- Table 2 : Summary of Micellar Stability parameter and Micellar Association parameter data
- Table 3 : Summary of Micellar Association data and PO retention
- Table 4 : Summary of piroctone olamine scalp retention data
- Table 5 : Summary of anti-dandruff clinical evaluationDOI : https://doi.org/10.1111/ics.12835 En ligne : https://drive.google.com/file/d/15x6UeCPskFUzXhclO36lFCI1b11GE8SC/view?usp=share [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=39173
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 45, N° 2 (03-04/2023) . - p. 236-245[article]Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Role of scalp health in achieving optimal hair growth and retention / Antonella Tosti in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° S1 (11/2021)
[article]
Titre : Role of scalp health in achieving optimal hair growth and retention Type de document : document électronique Auteurs : Antonella Tosti, Auteur ; James R. Schwartz, Auteur Année de publication : 2021 Article en page(s) : p. 1-8 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Cheveux -- Croissance
Cuir chevelu
Cuir chevelu -- Maladies
Dermatologie
Stress oxydatifIndex. décimale : 668.5 Parfums et cosmétiques Résumé : We have conducted a thorough review of the literature to assess the evidence for supporting a cause-and-effect linkage between scalp condition and resultant hair condition. Over 20 epidemiological studies have been published covering a wide range of abnormal scalp conditions in which consequent impacts to the hair have been documented. A treatment study was conducted to demonstrate not only that impaired scalp condition led to impaired hair quality but that the impacts to hair are reversible upon normalization of the scalp condition. A proposed explanation involves the impact of scalp oxidative stress, which is part of the etiology of these scalp conditions as well as normal aging, in interfering with the normal keratinization of the pre-emergent hair cuticle. This perturbed cuticle impedes normal fiber anchorage and emerges more brittle and fragile than normal cuticle leading to accelerated physical degradation, mirroring the effects of chronological aging of the hair fiber. The consequences of the rapid cuticle degradation result in hair that is more vulnerable to mechanical insults and compromised overall quality. Note de contenu : - EPIDEMIOLOGICAL STUDIES EVALUATING IMPACT OF COMPROMISED SCALP CONDITIONS TO HAIR : Psoriasis - Dandruff/seborrhoeic dermatitis - Atopic dermatitis - Tinea capitis - Pityriasis versicolor
- TREATMENT STUDY EVALUATING IMPACT OF COMPROMISED SCALP CONDITIONS TO HAIR
- Table 1 : Summary of epidemiological studies of various scalp conditionsDOI : https://doi.org/10.1111/ics.12708 En ligne : https://drive.google.com/file/d/1fo6k3wmCdRbDKYW33qL18u-njmbeYsDg/view?usp=shari [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=36874
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° S1 (11/2021) . - p. 1-8[article]Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Scalp application of antioxidants improves scalp condition and reduces hair shedding in a 24-week randomized, double-blind, placebo-controlled clinical trial / Michael G. Davis in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° S1 (11/2021)
[article]
Titre : Scalp application of antioxidants improves scalp condition and reduces hair shedding in a 24-week randomized, double-blind, placebo-controlled clinical trial Type de document : document électronique Auteurs : Michael G. Davis, Auteur ; Melissa P. Piliang, Auteur ; Wilma F. Bergfeld, Auteur ; Tamara L. Caterino, Auteur ; Brian K. Fisher, Auteur ; Jarek P. Sacha, Auteur ; Gregory J. Carr, Auteur ; Laura T. Moulton, Auteur ; Deborah J. Whittenbarger, Auteur ; James R. Schwartz, Auteur Année de publication : 2021 Article en page(s) : p. 14-25 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Alopécie
Antioxydants
Cheveux -- Croissance
Cheveux -- Soins et hygiène
Cosmétiques
Cuir chevelu -- Soins et hygiène
Dermo-cosmétologie
Formulation (Génie chimique)
Produits capillaires
StatistiqueIndex. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Increasing hair fullness is a global unmet need for many men and women. An approach to the problem is to decrease hair fall or shedding by reducing scalp stratum corneum oxidation and barrier damage to increase hair retention. This study evaluated a combination of functional antioxidants and barrier-enhancing cosmetic ingredients to improve scalp condition thereby enabling stronger hair anchorage and longer retention.
- Methods : Male and female subjects with normal scalp condition and self-perceived hair thinning participated in a 24-week, double-blind, placebo-controlled, randomized clinical study assessing either a regimen of treatment shampoo and leave-on treatment containing functional antioxidant and barrier-enhancing agents or an identical placebo chassis shampoo control. The functional ingredients were piroctone olamine, zinc pyrithione, zinc carbonate, niacinamide, panthenol and caffeine. At baseline and after 8, 16 and 24 weeks of product use, several measurements were taken: hair shedding, total hair count (by phototrichogram), hair samples, TEWL and evaluation of biomarkers of scalp and hair conditions. Subjects also completed self-assessment questionnaires.
- Results : Statistically significant effects for functional ingredient-containing treatment regimen versus a placebo control shampoo formulation were observed for reduced hair shedding, increased total hair count, reduced TEWL and improvement in scalp biomarker values. Subjects also noticed these improvements assessed via self-assessment questionnaires.
- Conclusions : These results establish that the use of functional antioxidant and barrier-enhancing agents to further improve scalp condition can enable a reduction in hair shedding and thus an increase in perceived hair fullness. The underlying improvements in scalp condition suggest the hair benefits were achieved as a result of improved scalp skin barrier and scalp condition leading to a viable preventative approach for hair thinning.Note de contenu : - MATERIALS AND METHODS : Hair products - Study design and subjects
- RESULTS : Canfield total hair count - Hair shedding - Hair diameter - Subject self-assessments
- Table 1 : Compositions of Treatment formulations
- Table 2 : Hair and scalp measurement schedule per clinical site visit
Statistics
Table 3 : Subject hair and scalp self-assessment questionnaire responsesDOI : https://doi.org/10.1111/ics.12734 En ligne : https://drive.google.com/file/d/1on_BgkcGCHsdoJ6P-2aQ4TsxsE731KNh/view?usp=shari [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=36876
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° S1 (11/2021) . - p. 14-25[article]Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Scalp application of the antioxidant piroctone olamine reduces hair shedding in an 8-week randomized, double-blind, placebo-controlled clinical study / Michael G. Davis in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° S1 (11/2021)
[article]
Titre : Scalp application of the antioxidant piroctone olamine reduces hair shedding in an 8-week randomized, double-blind, placebo-controlled clinical study Type de document : document électronique Auteurs : Michael G. Davis, Auteur ; Melissa P. Piliang, Auteur ; Wilma F. Bergfeld, Auteur ; Tamara L. Caterino, Auteur ; Brian K. Fisher, Auteur ; Jarek P. Sacha, Auteur ; Greg J. Griffin, Auteur ; Laura T. Moulton, Auteur ; Deborah J. Whittenbarger, Auteur ; Supriya Punyani, Auteur ; James R. Schwartz, Auteur Année de publication : 2021 Article en page(s) : p. 26-33 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Alopécie
Antioxydants
Barrière cutanée
Cheveux -- Croissance
Cheveux -- Soins et hygiène
Cosmétiques
Cuir chevelu -- Soins et hygiène
Dermo-cosmétologie
Evaluation
Formulation (Génie chimique)
shampooingsIndex. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Increasing scalp hair fullness is a global unmet consumer need. An approach to decrease hair shedding by reducing scalp stratum corneum oxidation via a combination of antioxidant and barrier-enhancing technologies has been previously demonstrated. The purpose of this study was to test the effectiveness of the individual antioxidant piroctone olamine in two different product forms (shampoo or leave-on product) for activity to improve hair retention.
- Methods : Female subjects with self-perceived hair thinning participated in an 8-week, double-blind, placebo-controlled, randomized clinical study to evaluate either a piroctone olamine (PO) containing shampoo or a PO containing leave on treatment, each relative to their corresponding placebo formulation Too many periods. Results for phototrichograms, TEWL, and biomarker analysis of scalp condition for the shampoo treatments are discussed. Phototrichogram results are shared for the assessment of the leave on treatment.
- Results : Statistically significant increases in hair amount were observed by phototrichogram after use of both PO-containing products versus placebo formulations. The PO shampoo treatment also significantly decreased oxidative stress on the hair and scalp, and improved scalp condition as assessed by TEWL and scalp biomarker values.
- Conclusion : These results illustrate the effectiveness of a cosmetic antioxidant to improve scalp condition thereby improving hair retention. The observed improvements in scalp condition are consistent with previous reports with other antioxidant technologies and suggest that the hair retention effect was achieved by preventing oxidative damage to the scalp.Note de contenu : - MATERIALS AND METHODS : Study design and subjects - Study design and sample size for assessment of the shampoo treatments - Study design and sample size for assessment of the leave-on treatments - Study procedures - Statistics
- RESULTS : Total hair counts
Table 1 : Compositions of treatment formulationsDOI : https://doi.org/10.1111/ics.12737 En ligne : https://drive.google.com/file/d/1fO1cZSHgD02ug0rwQfzam1vGWqCNfkae/view?usp=shari [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=36877
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° S1 (11/2021) . - p. 26-33[article]Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Therapeutic efficacy of anti-dandruff shampoos : A randomized clinical trial comparing products based on potentiated zinc pyrithione and zinc pyrithione/climbazole / James R. Schwartz in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 35, N° 4 (08/2013)
[article]
Titre : Therapeutic efficacy of anti-dandruff shampoos : A randomized clinical trial comparing products based on potentiated zinc pyrithione and zinc pyrithione/climbazole Type de document : texte imprimé Auteurs : James R. Schwartz, Auteur ; R. A. Bacon, Auteur ; R. Shah, Auteur ; H. Mizoguchi, Auteur ; A. Tosti, Auteur Année de publication : 2013 Article en page(s) : p. 381-387 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antifongiques
Antipelliculaires
Barrière cutanée
Climbazole
Cuir chevelu -- Maladies
Cuir chevelu -- Soins et hygiène
Diffusion (physique)
Peau -- Physiologie
Pyrithione de zinc
shampooingsIndex. décimale : 668.5 Parfums et cosmétiques Résumé : Objectifs : Les pellicules représentent un état chronique récurrent du cuir chevelu qui a un impact négatif sur la qualité de vie des personnes atteintes. L'utilisation régulière de shampooings anti-fongiques offre une stratégie thérapeutique éprouvée pour améliorer les symptômes les plus courants de flocons et les démangeaisons. Deux approches récentes pour accroître l'efficacité de shampooings antifongiques, soit optimisent la bio-disponibilité de la matière active, soit procèdent à l'addition d'une deuxième matière active. Notre objectif est de comparer l'efficacité thérapeutique de ces deux approches – l'optimisation de la bio-disponibilité du zinc pyrithione (ZPT) actif ou la combinaison du ZPT avec un actif secondaire.
Methodes : L'activité anti-fongique des shampooings représentant chacune de ces approches a été évaluée in vitro en utilisant une méthode standard de microbiologie. La distribution spatiale des particules ZPT dans l'infundibulum folliculaire a été évaluée in vivo en utilisant une nouvelle méthode de microscopie confocale. L'efficacité clinique a été évaluée dans un essai randomisé, en double aveugle impliquant 620 sujets masculins et féminins, à l'aide de la mesure de desquamation du cuir chevelu et du niveau d'histamine épidermique comme critères.
Resultats : La formule du shampooing avec ZPT à bio-disponibilité optimisée, nommée ‘ZPT potentialisé’ montrait un plus grand pouvoir anti-fongique que le shampooing ‘Actif Double’ contenant à la fois du ZPT et du climbazole. La formule de ‘ZPT potentialisé’ a également livré plus ZPT à l'infundibulum inférieur que le shampooing ‘Actif Double’. Un traitement de quatre semaines avec la formule de ZPT potentialisé a donné lieu à une efficacité clinique supérieure à celle du produit aux deux actifs, aux quatre points dans le temps pour les effets d'histamine et de desquamation de l'épiderme.
Conclusion : Ces résultats soulignent le rôle crucial que la formule du shampooing joue dans la réalisation de la pleine activité des matières actives. En optimisant le véhicule de déposition, l'activité antifongique améliorée et la distribution spatiale agrandie de l'actif résultent dans une plus notable amélioration des symptômes qu'un produit à deux matières actives. L'efficacité thérapeutique d'un produit basé sur une formulation complexe comme un shampooing doit être considérée dans une perspective du produit entier.Note de contenu : - METHODS : Measurement of anti-fungal activity - Measurement of infundibular delivery of zinc pyrithione in vivo - Clinical efficacy study design - Assessment of flaking severity - Assessment of histamine from scalp surface - Test products - Statistical analysis
- RESULTS : Anti-fungal activity of anti-dandruff shampoos - Infundibular delivery of ZPT - Evaluation of anti-dandruff clinical efficacyDOI : 10.1111/ics.12055 En ligne : http://onlinelibrary.wiley.com/doi/10.1111/ics.12055 Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=19190
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 35, N° 4 (08/2013) . - p. 381-387[article]Réservation
Réserver ce document
Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité 15415 - Périodique Bibliothèque principale Documentaires Disponible