[article]
| Titre : |
Dermal-epidermal junction : a key target for anti-ageing |
| Type de document : |
texte imprimé |
| Auteurs : |
Jean-François Nicolaÿ, Auteur ; Emmanuel Coste, Auteur ; Mathilde Fréchet, Auteur |
| Année de publication : |
2015 |
| Article en page(s) : |
p. 65-68 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge
Peau -- Soins et hygiène
Produits hydratants
RhamnoseLe Rhamnose est un désoxyose, précisément un désoxy-hexose du mannose.
Le rhamnose est un 6-désoxy-hexose du type aldose, il est constitué d’une chaîne de 5 éléments carbone ainsi que d’une fonction aldéhyde. Il peut être classifié soit comme un méthyl-pentose ou soit comme un 6-déoxy-hexose.
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
The dermal epidermal junction (DEJ) is a complex structure (Fig. 1) primarily responsible for epidermis to dermis attachment. The DEJ thus warrants cohesion and mechanical resistance of the skin. It also behaves as a selective permeability barrier controlling cell migration (immune cells, for example), and molecular exchanges (growth factors and nutrients, stress signals). Epidermal cells'interaction with the DEJ regulates their proliferation, differentiation and migraton, which is critical for epiderma renewal, barrier function setup, and wound healing.
Intrinsic and extrinsic ageing are associated with important DEJ structural modifications including flattening (loss of rete ridges), duplication and thinning (Fig. 3b). At molecular level, there is a decreased expression of the main DEJ constituent-proteins : collagens type IV, VII and XVII, laminin 5 and integrin β4. All these changes likely participate in structural and functional changes associated with ageing skin (elasticity loss, higher fragility, decreased resilience to stress, impaired wound healing). In photo-aged skin, degradation of some specific DEJ constituents such as heparan sulfate causes permeability modifications that were reported to participate in age spots formation.
Therefore a large array of cosmetic benefits can be expecteed from DEJ protection and repair. Here we describe the properties of an original bioavailable rhamnose derivative, its mechanism of action, and clinical improvements obtained after four weeks of treatement. |
| Note de contenu : |
- Design of a bioavailable rhamnose derivative
- Sirhamnose efficacy : ex vivo study
- Efficacy : clinical study
- Skin hydration
- Skin structure
- Skin tone
- Age spots |
| En ligne : |
https://drive.google.com/file/d/168yWCB7m_SLGEqjRGGjaQgKOAMzr3Qf0/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=24942 |
in PERSONAL CARE EUROPE > Vol. 8, N° 6 (11/2015) . - p. 65-68
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Dermal-epidermal junction : a key target for anti-ageing in PERSONAL CARE EUROPE, Vol. 8, N° 6 (11/2015)
