| Résumé : |
Each cell has to anabolise and catabolise active ingredients every day, communicating with and replying to an extemal and internal environment, continually evolving. To be involved in these activities, the tells modify the composition of their membranes by an elaborate system capable to add or remove the proteins embedded into this protective envelope, such as receptors, ionic channels, and the transporters. By the mechanism of the cellular exocytosis, all the synthesised or imported ingredients arrive to their final destination : the cellular membrane or the extracellular space. By the inverted mechanism of endocytosis, the tells may import into their interior space all the components of the cellular membrane to be utilised or catabolised. Alternatively, they may capture many nutrients, such as vitamins, lipids, amino acids, etc, transporting them into the cytosol where they are used for the different biosynthetic processes. These main biological activities of all the organs, such as the skin, maintain the human body in equilibrium.
The main objective of cosmetic dermatology is, therefore, the development of new active ingredients, able to maintain the skin homeostasis and slow down its ageing process. The use of ingredients and means, capable to mimic the regular activity of ECM, modulating the skin reparative systems by the regular synthesis of collagen and elastic fibres, is, therefore, among the main goals of the dermatological and cosmetic companies.
Chitin nanofibril is a promising ingredient that, bonded with other natural polymers to form nanoparticles or nanofibres, seems to represent an innovative bioactive ingredient capable to modulate the skin cell's daily life, protecting its bio-structure from the environmental aggressions. Moreover, the possibility CN has to act in accarding with the NICE-TCM approach, is a further reason to increase the studies on this fascinating natural polymer, for better understanding its real, mechanism of action. This is the future challenge of our research group. |
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Neurocosmetic activity of chitin nanofibrils in PERSONAL CARE EUROPE, Vol. 8, N° 3 (04/2015)
