| Titre : |
Noninvasive in situ assessment of structural alteration of human dermis caused by photoaging using a novel collagen-specific imaging technique |
| Type de document : |
document électronique |
| Auteurs : |
Toyonobu Yamashita, Auteur ; Yuki Ogura, Auteur ; Yuji Tanaka, Auteur ; Ryosuke Tanaka, Auteur ; Takeshi Yasui, Auteur ; Tsutomu Araki, Auteur ; Tetsuji Hirao, Auteur |
| Année de publication : |
2013 |
| Article en page(s) : |
p. 3-7 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Collagène
Génération de seconde harmoniqueLa génération de seconde harmonique (GSH) également appelé doublage de fréquence) est un processus d'optique non-linéaire dans lequel des photons interagissant avec un matériau non-linéaire sont combinés pour former de nouveaux photons avec le double de l'énergie, donc avec le double de la fréquence ou la moitié de la longueur d'onde des photons initiaux.
Imagerie médicale
Microscopie
Photovieillissement (dermatologie)
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Specific visualization and assessment of human collagen fibers were demonstrated using a developed second-harmonic-generation (SHG) microscope equipped with a Cr:forsterite laser (1250 nm). Initially, we examined the specific sensitivity of SHG imaging for collagen fibers using excised human skin specimens. Age-related dermal alterations in female subjects were then evaluated by means of SHG microscopy. The developed SHG microscope enabled us to observe the collagen fibers in the skin sections ; their SHG images correlated well with the Elastica-van-Gieson-stained sections of dermal fibers. In vivo imaging of human skin with a wide field of view as also achieved. En face SHG images of facial skin of female subjects of different ages showed the structural alterations in the collagen fiber network. Additional image analysis of SHG images based on two-dimensional Fourier transformation also reflected age-related alterations. In conclusion, this proposed methodology can be a powerful tool in fields such as anti-aging dermatology and validation of the efficacy of cosmetic products. |
| Note de contenu : |
- MATERIALS AND METHODS : Optical imaging systems - Specific sensitivity to collagen fibers - Evaluation of human skin
- RESULTS AND DISCUSSION : Comparison of SHG images and elastica-van-Gieson stained section images - In vivo visualization of human cheek skin - Age-related alteration of collagen fibers |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=17826 |
in IFSCC MAGAZINE > Vol. 16, N° 1 (01-02-03/2013) . - p. 3-7
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