| Titre : |
New anti-ageing strategy focuses on mitochondria |
| Type de document : |
texte imprimé |
| Auteurs : |
Isabelle Imbert, Auteur ; Anne-Françoise Clay, Auteur ; Joël Mantelin, Auteur ; Karine Cucumel, Auteur |
| Année de publication : |
2008 |
| Article en page(s) : |
p. 79-85 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge
Cosmétiques
Dermo-cosmétologie
Mitochondries
Peau -- Soins et hygiène
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Mitochondria play a central role in metabolism and bioenergetics, and their main macromolecular structures have been determined down to the atomic level. However, the study of mitochondria is far from exhausted. Recent understanding of the essential role of mitochondria in the ageing process has raised considerable interest in a new anti-ageing approach that involves the development of new target molecules to protect against mitochondrial ageing and dysfunction. Several characteristics make motochondria unique. They are matrenally inherited and have their own unique DNA as well as the machinery to produce their own ribonucleic acid (RNA) and many proteins. Mitochondria are involved in many biological pathways such as skin cell proliferation and repair and regulation of the cellular redox state. In the skin, the number and activity of mitochondria are related to the differentiation process: terminally differentiated keratinocytes contain no mitochondria whereas basal keratinocytes and fibroblasts hold mitochondria that allow these cells to sustain their metabolic activities. Cellular protection against mitochondrial ageing would enable the cellular redox state in balance and to avoid mitochondrial dysfunction that would induce further cell damage. Strong interest in protecting mitochondrial DNA has been confirmed by its higher capacity to accumulate mutations and its lower capacity for repair compared with nuclear DNA. |
| Note de contenu : |
- Key role in cell biology
- Two-membrane structure
- Mitochondria genome (mtDNA)
- Mitochondrial functions : 1. Energy production and oxidative phosphorylation - 2. Energy dissipation - 3. Production of reactive oxygen species - 4. Apoptosis
- Mitochondrial theory of ageing : 1. ROS production and the energy crisis - 2. The vicious cycle theory - 3. ROS production and mtDNA damage - 4. Altered structures - 5. Impaired mitochondrial recycling - 6. Impaired mitochondrial division (fission) - 7. Mitochondria, sirtuins and lifespan
- Cosmetic target strategies addressing mitochondria |
| En ligne : |
https://drive.google.com/file/d/151NioqstjBc1wMyWkm7hcMh1h6AjbtGM/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=22099 |
in PERSONAL CARE EUROPE > Vol. 1, N° 1 (09/2008) . - p. 79-85
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New anti-ageing strategy focuses on mitochondria in PERSONAL CARE EUROPE, Vol. 1, N° 1 (09/2008)
